Progressive left lower extremity weakness in a patient with multiple myeloma: A diagnostic dilemma
AffiliationUniv Arizona, Dept Med
left lower extremity weakness
metal artifact reduction protocol
MetadataShow full item record
PublisherSAGE PUBLICATIONS INC
CitationSardar, M., Shaikh, N., Malik, S. U., Faridi, W., Balshan, E., & Maniar, M. (2019). Progressive left lower extremity weakness in a patient with multiple myeloma: A diagnostic dilemma. SAGE Open Medical Case Reports. https://doi.org/10.1177/2050313X19833506
JournalSAGE OPEN MEDICAL CASE REPORTS
Rights© The Author(s) 2019.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractExtramedullary plasmacytoma is a type of plasma cell dyscrasia that can present as solitary tumor or secondary to multiple myeloma. We experienced a case of intramuscular plasmacytoma in the left thigh muscles of a patient secondary to multiple myeloma. A 73-year-old male with relapsed multiple myeloma and bilateral hip arthroplasty complained of lxeft lower limb weakness and hip pain 3 months after relapse. He underwent contrast-enhanced magnetic resonance imaging of lumbar spine and hip which was inconclusive. Subsequently, patient had multiple admissions for progressive lower limb weakness. His clinical course was complicated by a biopsy-proven plasmacytoma of the neck. He received localized radiation therapy to the neck in addition to a change in multiple myeloma chemotherapy regimen, resulting in resolution of the neck mass but his left lower extremity weakness continued to worsen. Repeat magnetic resonance imaging of hip and spine revealed an intramuscular mass in left thigh which was consistent with the diagnosis of extramedullary plasmacytoma on biopsy. Localized radiation to the thigh accompanied with a change in chemotherapy improved his symptoms and a significant reduction in size of plasmacytoma was observed. When an unexplained lower limb weakness is encountered with a history of multiple myeloma, secondary intramuscular plasmacytoma should be considered.
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- Issue date: 2012 Jan
- Plasmacytoma as a cause of small bowel obstruction in a virgin abdomen in a patient with multiple myeloma: a case report.
- Authors: Mwinyogle AA, Bhatt A, Kapisoda K, Somerville J, Cunningham SC
- Issue date: 2019 May 17
- Primary extramedullary plasmacytoma with diffuse lymph node involvement: a case report and review of the literature.
- Authors: Naymagon L, Abdul-Hay M
- Issue date: 2019 May 22
- Recurrent extramedullary plasmacytoma in asymptomatic multiple myeloma: a case report.
- Authors: Schols SE, Tick LL
- Issue date: 2015 Feb 19
- [A case of myeloma kidney complicated by extramedullary plasmacytoma with massive bleeding].
- Authors: Inoue T, Okada H, Shioda K, Takahira S, Kanno Y, Sugahara S, Nakamoto H, Suzuki H
- Issue date: 2001 May