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dc.contributor.advisorPatanwala, Asad
dc.contributor.authorMunoz, Jonis
dc.contributor.authorReyes, Dana
dc.date.accessioned2019-06-28T21:17:54Z
dc.date.available2019-06-28T21:17:54Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10150/633212
dc.descriptionClass of 2018 Abstracten_US
dc.description.abstractObjectives: The purpose of this project was to assess appropriateness of alteplase (tPA) administration in patients undergoing magnetic resonance imaging (MRI) at Banner-University Medical Center Tucson (BUMC-T) and identify interruptions in therapy that could have been prevented. Methods: This descriptive quality improvement project evaluated retrospective data from the electronic health records at BUMC-T. Data was collected from patient charts using Epic. The data collection form included items based on demographics, tPA, symptoms and severity, utilization of computerized tomography, MRI, interventional radiology (IR), and complications. Wilcoxon Rank-sum test was used to compare the door-to-needle times if patients did or did not receive an MRI. Fisher’s exact test was used to compare the proportion of patients with interruption of infusion with or without emergent MRI (P<0.050). Main Results: Ninety-six patients received tPA for acute ischemic stroke with 13 having an interruption in infusion. Reasons documented were placed into 4 categories: MRI related, blood pressure related, adverse reactions related to tPA, or other. Four of 13 interruptions were related to an emergent MRI. This was not statistically significant (p>0.050). The remainder were not preventable as tPA was discontinued because of an adverse event. Patients that received an MRI received tPA faster than those patients who did not receive an MRI (48 minutes versus 63 minutes, respectively) (P=0.006). Conclusions: Alteplase interruptions did not occur more frequently in patients who received MRI. However, all preventable interruptions were due to MRI. Alteplase administration logistics should be optimized to minimize any preventable interruptions in therapy.en_US
dc.language.isoen_USen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author.en_US
dc.subjectalteplaseen_US
dc.subjecttPAen_US
dc.subjectMRIen_US
dc.subjectischemic strokeen_US
dc.subject.meshTissue Plasminogen Activatoren_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshStrokeen_US
dc.subject.meshIschemiaen_US
dc.titleEffect of emergent magnetic resonance imaging on alteplase utilization for acute ischemic strokeen_US
dc.typetexten_US
dc.typeElectronic Reporten_US
dc.contributor.departmentCollege of Pharmacy, The University of Arizonaen_US
dc.description.collectioninformationThis item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.en_US
refterms.dateFOA2019-05-16T00:00:00Z


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