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dc.contributor.advisorErstad, Brian
dc.contributor.authorOman, Nathaniel
dc.contributor.authorVraney, Jamie
dc.date.accessioned2019-06-28T21:27:13Z
dc.date.available2019-06-28T21:27:13Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10150/633257
dc.descriptionClass of 2018 Abstracten_US
dc.description.abstractSpecific Aims: To assess appropriateness of prescribing practices of oseltamivir to package insert recommendations and identify significant differences in length of intensive care unit (ICU) stay, length of mechanical ventilation, and mortality in critically ill patients with influenza who received oseltamivir within 48 hours of symptom onset compared to those who did not. Methods: Patients were included in this retrospective, Institutional Review Board (IRB)-approved chart review if they were at least 18 years old with confirmed diagnosis of influenza in an intensive care unit at Banner University Medical Center – Tucson from 2015-2016. Categorical data were analyzed using Fisher’s exact test. Continuous variables were analyzed using a two-sample T-test assuming equal variances. The alpha priori level was 0.05. Main Results: All patients with confirmed influenza were treated with oseltamivir. 52% of patients received oseltamivir within 48 hours of symptom onset and 55% received an appropriate dose based on renal function. 30% of patients received oseltamivir for the recommended 5-day duration. Oseltamivir was prescribed with correct onset, dose, and duration based on package insert recommendations in only 3 instances (9.1%). No difference was seen in ICU length of stay (p = 0.67), hours on mechanical ventilation (p = 0.41), or mortality (p = 0.34) in those patients who received oseltamivir within 48 hours of symptom onset versus those who did not. Conclusions: High variation existed in observed oseltamivir prescribing practices. Future studies should incorporate multiple influenza seasons to permit a larger sample size and involve multiple facilities to allow for greater generalizability.en_US
dc.language.isoen_USen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author.en_US
dc.subjectoseltamiviren_US
dc.subjectfluen_US
dc.subjectinfluenzaen_US
dc.subjecthospital stayen_US
dc.subjectmechanical ventilationen_US
dc.subjectmortalityen_US
dc.subject.meshOseltamiviren_US
dc.subject.meshInfluenza, Humanen_US
dc.subject.meshDrug Therapyen_US
dc.subject.meshRespiration, Artificialen_US
dc.subject.meshLength of Stayen_US
dc.subject.meshMortalityen_US
dc.titleOseltamivir Prescribing Practices for Influenza in Patients in the Intensive Care Unit and Associated Outcomesen_US
dc.typetexten_US
dc.typeElectronic Reporten_US
dc.contributor.departmentCollege of Pharmacy, The University of Arizonaen_US
dc.description.collectioninformationThis item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Associate Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.en_US


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