Dietary flavonoids improve urinary arsenic elimination among Mexican women
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Quiller, GrantMérida-Ortega, Ángel
Rothenberg, Stephen J
Cebrián, Mariano E
Gandolfi, A Jay
Franco-Marina, Francisco
López-Carrillo, Lizbeth
Affiliation
Univ Arizona, Coll Pharm, Dept Pharmacol & ToxicolIssue Date
2018-07
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PERGAMON-ELSEVIER SCIENCE LTDCitation
Quiller, G., Mérida-Ortega, Á., Rothenberg, S. J., Cebrián, M. E., Gandolfi, A. J., Franco-Marina, F., & López-Carrillo, L. (2018). Dietary flavonoids improve urinary arsenic elimination among Mexican women. Nutrition research, 55, 65-71.Journal
NUTRITION RESEARCHRights
© 2018 Elsevier Inc. All rights reserved.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Inorganic arsenic (iAs) exposure increases risk of several diseases, including cancer. Some nutrients such as flavonoids enhance glutathione activity, which in turn play a key role in iAs elimination. Our objective was to explore whether dietary non-soy flavonoids are associated with iAs metabolism. We hypothesized that the intake of flavonoids belonging to the following groups, flavan-3-ols, flavone, flavonol, flavanone, and anthocyanidin, is positively associated with urinary dimethylarsinic acid (DMA), which is the most soluble iAs metabolite excreted. We performed a cross-sectional study that included 1027 women living in an arsenic-contaminated area of northern Mexico. Flavonoid intake was estimated using a validated food frequency questionnaire. Concentration of urinary iAs and its metabolites (monomethylarsonic acid and DMA) were determined by high performance liquid chromatography ICP-MS. Results showed positive significant associations between DMA and the flavonoid groups flava-3-ols (beta= 0.0112) and flavones (beta= 0.0144), as well as the individual intake of apigenin (beta= 0.0115), luteolin (beta= 0.0138), and eriodictyol (beta= 0.0026). Our findings suggest that certain non-soy flavonoids may improve iAs elimination; however, there is still very limited information available regarding the consumption of flavonoids and iAs metabolism. (C) 2018 Elsevier Inc. All rights reserved.Note
12 month embargo; available online 21 April 2018.ISSN
1879-0739PubMed ID
29914629Version
Final accepted manuscriptSponsors
CONACYT Fondo Sectorial de Investigacion en Salud y Seguridad Social [2005-2-14373, 2009-1-111384, 2010-1-140962, POCPN 2013-01-215464, FOSISS 272632]; National Center on Minority Health and Health Disparities of the National Institutes of Health [MD 001452]ae974a485f413a2113503eed53cd6c53
10.1016/j.nutres.2018.04.012
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