Dietary flavonoids improve urinary arsenic elimination among Mexican women
Rothenberg, Stephen J
Cebrián, Mariano E
Gandolfi, A Jay
AffiliationUniv Arizona, Coll Pharm, Dept Pharmacol & Toxicol
MetadataShow full item record
PublisherPERGAMON-ELSEVIER SCIENCE LTD
CitationQuiller, G., Mérida-Ortega, Á., Rothenberg, S. J., Cebrián, M. E., Gandolfi, A. J., Franco-Marina, F., & López-Carrillo, L. (2018). Dietary flavonoids improve urinary arsenic elimination among Mexican women. Nutrition research, 55, 65-71.
Rights© 2018 Elsevier Inc. All rights reserved.
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AbstractInorganic arsenic (iAs) exposure increases risk of several diseases, including cancer. Some nutrients such as flavonoids enhance glutathione activity, which in turn play a key role in iAs elimination. Our objective was to explore whether dietary non-soy flavonoids are associated with iAs metabolism. We hypothesized that the intake of flavonoids belonging to the following groups, flavan-3-ols, flavone, flavonol, flavanone, and anthocyanidin, is positively associated with urinary dimethylarsinic acid (DMA), which is the most soluble iAs metabolite excreted. We performed a cross-sectional study that included 1027 women living in an arsenic-contaminated area of northern Mexico. Flavonoid intake was estimated using a validated food frequency questionnaire. Concentration of urinary iAs and its metabolites (monomethylarsonic acid and DMA) were determined by high performance liquid chromatography ICP-MS. Results showed positive significant associations between DMA and the flavonoid groups flava-3-ols (beta= 0.0112) and flavones (beta= 0.0144), as well as the individual intake of apigenin (beta= 0.0115), luteolin (beta= 0.0138), and eriodictyol (beta= 0.0026). Our findings suggest that certain non-soy flavonoids may improve iAs elimination; however, there is still very limited information available regarding the consumption of flavonoids and iAs metabolism. (C) 2018 Elsevier Inc. All rights reserved.
Note12 month embargo; available online 21 April 2018.
VersionFinal accepted manuscript
SponsorsCONACYT Fondo Sectorial de Investigacion en Salud y Seguridad Social [2005-2-14373, 2009-1-111384, 2010-1-140962, POCPN 2013-01-215464, FOSISS 272632]; National Center on Minority Health and Health Disparities of the National Institutes of Health [MD 001452]