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    Dietary flavonoids improve urinary arsenic elimination among Mexican women

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    Author
    Quiller, Grant
    Mérida-Ortega, Ángel
    Rothenberg, Stephen J
    Cebrián, Mariano E
    Gandolfi, A Jay
    Franco-Marina, Francisco
    López-Carrillo, Lizbeth
    Affiliation
    Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol
    Issue Date
    2018-07
    Keywords
    Arsenic metabolism
    Cross-sectional study
    Flavonoids
    Mexico
    
    Metadata
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    Publisher
    PERGAMON-ELSEVIER SCIENCE LTD
    Citation
    Quiller, G., Mérida-Ortega, Á., Rothenberg, S. J., Cebrián, M. E., Gandolfi, A. J., Franco-Marina, F., & López-Carrillo, L. (2018). Dietary flavonoids improve urinary arsenic elimination among Mexican women. Nutrition research, 55, 65-71.
    Journal
    NUTRITION RESEARCH
    Rights
    © 2018 Elsevier Inc. All rights reserved.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Inorganic arsenic (iAs) exposure increases risk of several diseases, including cancer. Some nutrients such as flavonoids enhance glutathione activity, which in turn play a key role in iAs elimination. Our objective was to explore whether dietary non-soy flavonoids are associated with iAs metabolism. We hypothesized that the intake of flavonoids belonging to the following groups, flavan-3-ols, flavone, flavonol, flavanone, and anthocyanidin, is positively associated with urinary dimethylarsinic acid (DMA), which is the most soluble iAs metabolite excreted. We performed a cross-sectional study that included 1027 women living in an arsenic-contaminated area of northern Mexico. Flavonoid intake was estimated using a validated food frequency questionnaire. Concentration of urinary iAs and its metabolites (monomethylarsonic acid and DMA) were determined by high performance liquid chromatography ICP-MS. Results showed positive significant associations between DMA and the flavonoid groups flava-3-ols (beta= 0.0112) and flavones (beta= 0.0144), as well as the individual intake of apigenin (beta= 0.0115), luteolin (beta= 0.0138), and eriodictyol (beta= 0.0026). Our findings suggest that certain non-soy flavonoids may improve iAs elimination; however, there is still very limited information available regarding the consumption of flavonoids and iAs metabolism. (C) 2018 Elsevier Inc. All rights reserved.
    Note
    12 month embargo; available online 21 April 2018.
    ISSN
    1879-0739
    PubMed ID
    29914629
    DOI
    10.1016/j.nutres.2018.04.012
    Version
    Final accepted manuscript
    Sponsors
    CONACYT Fondo Sectorial de Investigacion en Salud y Seguridad Social [2005-2-14373, 2009-1-111384, 2010-1-140962, POCPN 2013-01-215464, FOSISS 272632]; National Center on Minority Health and Health Disparities of the National Institutes of Health [MD 001452]
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.nutres.2018.04.012
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