A miniaturized, tethered, spectrally-encoded confocal endomicroscopy capsule
Grant, Catriona N
Giddings, Sarah L
Hesterberg, Paul E
Garber, John J
Katz, Aubrey J
Tearney, Guillermo J
AffiliationUniv Arizona, Coll Opt Sci
Univ Arizona, Dept Biomed Engn
Univ Arizona, Inst Bio5
reflectance confocal microcopy
spectrally encoded confocal microscopy
tethered capsule endomicroscopy
MetadataShow full item record
CitationKang, D. , Do, D. , Ryu, J. , Grant, C. N., Giddings, S. L., Rosenberg, M. , Hesterberg, P. E., Yuan, Q. , Garber, J. J., Katz, A. J. and Tearney, G. J. (2019), A miniaturized, tethered, spectrally‐encoded confocal endomicroscopy capsule. Lasers Surg. Med., 51: 452-458. doi:10.1002/lsm.23050
JournalLASERS IN SURGERY AND MEDICINE
Rights© 2019 Wiley Periodicals, Inc.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractBackground and Objective The tethered spectrally-encoded confocal endomicroscopy (SECM) capsule is an imaging device that once swallowed by an unsedated patient can visualize cellular morphologic changes associated with gastrointestinal (GI) tract diseases in vivo. Recently, we demonstrated a tethered SECM capsule for counting esophageal eosinophils in patients with eosinophilic esophagitis (EoE) in vivo. Yet, the current tethered SECM capsule is far too long to be widely utilized for imaging pediatric patients, who constitute a major portion of the EoE patient population. In this paper, we present a new tethered SECM capsule that is 33% shorter, has an easier and repeatable fabrication process, and produces images with reduced speckle noise. Materials and Methods The smaller SECM capsule utilized a miniature condenser to increase the fiber numerical aperture and reduce the capsule length. A custom 3D-printed holder was developed to enable easy and repeatable device fabrication. A dual-clad fiber (DCF) was used to reduce speckle noise. Results The fabricated SECM capsule (length = 20 mm; diameter = 7 mm) had a similar size and shape to a pediatric dietary supplement pill. The new capsule achieved optical sectioning thickness of 13.2 mu m with a small performance variation between devices of 1.7 mu m. Confocal images of human esophagus obtained in vivo showed the capability of this new device to clearly resolve microstructural epithelial details with reduced speckle noise. Conclusions We expect that the smaller size and better image performance of this new SECM capsule will greatly facilitate the clinical adoption of this technology in pediatric patients and will enable more accurate assessment of EoE-suspected tissues. Lasers Surg. Med. 51:452-458, 2019. (c) 2019 Wiley Periodicals, Inc.
Note12 month embargo; published online: 6 January 2019
VersionFinal accepted manuscript
SponsorsAmerican Partnership For Eosinophilic Disorders (APFED); National Institute of Diabetes and Digestive and Kidney Diseases [R01DK091923]; Tummala Family Foundation
- Tethered confocal endomicroscopy capsule for diagnosis and monitoring of eosinophilic esophagitis.
- Authors: Tabatabaei N, Kang D, Wu T, Kim M, Carruth RW, Leung J, Sauk JS, Shreffler W, Yuan Q, Katz A, Nishioka NS, Tearney GJ
- Issue date: 2013 Dec 13
- Large-area spectrally encoded confocal endomicroscopy of the human esophagus in vivo.
- Authors: Kang D, Schlachter SC, Carruth RW, Kim M, Wu T, Tabatabaei N, Soomro AR, Grant CN, Rosenberg M, Nishioka NS, Tearney GJ
- Issue date: 2017 Mar
- Reflectance confocal microscopy for the diagnosis of eosinophilic esophagitis: a pilot study conducted on biopsy specimens.
- Authors: Yoo H, Kang D, Katz AJ, Lauwers GY, Nishioka NS, Yagi Y, Tanpowpong P, Namati J, Bouma BE, Tearney GJ
- Issue date: 2011 Nov
- Endoscopic probe optics for spectrally encoded confocal microscopy.
- Authors: Kang D, Carruth RW, Kim M, Schlachter SC, Shishkov M, Woods K, Tabatabaei N, Wu T, Tearney GJ
- Issue date: 2013
- Miniature objective lens with variable focus for confocal endomicroscopy.
- Authors: Kim M, Kang D, Wu T, Tabatabaei N, Carruth RW, Martinez RV, Whitesides GM, Nakajima Y, Tearney GJ
- Issue date: 2014 Dec 1