• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Master's Theses
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Master's Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    A Penetration and Safety Assay for Generic Ophthalmic Drugs

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    azu_td_bme_0004_sip1_w.pdf
    Size:
    4.089Mb
    Format:
    PDF
    Download
    Author
    Orsinger, Gabriel
    Issue Date
    2010
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Generic topical ophthalmic medications are poorly regulated by the Food and Drug Administration, resulting in an uncertainty of generics' efficacy and safety and unnecessarily placing patients at risk. In 1999, more than 200 documented cases of corneal damage as severe as corneal melting were linked to the use of a generic formulation of diclofenac, which was consequently pulled from the market. These devastating iatrogenic effects demonstrate the need for stricter testing of generic ophthalmic drugs prior to reaching the public. This report addresses this urgent need by proposing an in vitro model for simultaneously predicting corneal penetration and epithelial toxicity of topical ophthalmic formulations. Penetration and safety of ophthalmic medications have been studied separately, but until now, the development of an assay to accurately predict both penetration and safety in parallel has been overlooked. In this report, recent and ongoing research will be reviewed to (1) elucidate the complexities of corneal penetration and the effects of topical ophthalmic formulations on corneal penetration, and (2) identify important characteristics of existing models to incorporate in the proposed in vitro penetration and safety assay. Critical features of the model proposed here include a trephinated porcine cornea from tissue discards affixed in a Franz diffusion cell, permitting concurrent drug penetration and epithelial health monitoring. A robust, cost-effective penetration and safety assay such as this would provide drug companies with a valuable tool to eliminate chances of future iatrogenic effects due to topical ophthalmic drugs.
    Type
    text
    Report-Reproduction (electronic)
    Degree Name
    M.S.
    Degree Level
    masters
    Degree Program
    Biomedical Engineering
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.