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    Quantitative T_2 Mapping in Cardiac MRI

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    Author
    Barr, Tomoe
    Issue Date
    2012
    Advisor
    Altbach, Maria
    
    Metadata
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    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    The thesis discusses a quantitative method to examine the myocardium using an MRdependant tissue parameter known as the spin-spin relaxation time, T 2. This parameter is related to cardiac pathologies, such as myocardial edema, or inflammation. The goal of my project was to optimize a data acquisition technique (double-inversion radial fast spin echo or DIR-RADFSE), previously developed in Dr. Altbach's lab, for cardiac MRI applications. The data collected with DIR-RADFSE can be used to calculate T2 via specialized reconstruction algorithms. First, the setups with DIR-RADFSE sequence were optimized with the goal of reducing artifacts due to aliasing, chemical shift, indirect echoes and cardiac motion (due to higher heart rates). Then, reproducibility studies were conducted on healthy controls to evaluate the reproducibility of the T2 values in the myocardium. The technique was also tested on patients who were undergoing a routine clinical examination. The results of this initial clinical study are presented in the thesis.
    Type
    text
    Thesis-Reproduction (electronic)
    Degree Name
    M.S.
    Degree Level
    masters
    Degree Program
    Biomedical Engineering
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

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