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dc.contributor.advisorHoying, James
dc.contributor.authorBudoff, Adam
dc.creatorBudoff, Adam
dc.date.accessioned2019-07-06T02:20:41Z
dc.date.available2019-07-06T02:20:41Z
dc.date.issued2000
dc.identifier.urihttp://hdl.handle.net/10150/633327
dc.description.abstractAngiogenesis is the process by which new blood vessels form from an existing vasculature. The degree of angiogenesis and the character of the resulting microvascular beds vary between different healing environments such as wound healing and tumor angiogenesis. These differences are due, in part, to qualitative and quantitative differences in the molecular function within the tissue undergoing angiogenesis. For this study, these two types of angiogenic environments were created in mice and characterized on a gene expression level by utilizing cDNA microarrays. A DNA microarray containing 58 mouse genes from many different molecular classes relevant to angiogenesis was manufactured and tested. Optimal conditions and protocols for the use of microarray technology were designed and implemented. Results show that a polymerinduced angiogenic wound healing response differs greatly in its transcription profile from a tumor, suggesting that different types of angiogenesis occur in different environments.
dc.language.isoen
dc.publisherThe University of Arizona.
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
dc.titleTranscription Profiling of Angiogensis using DNA Microarrays
dc.typetext
dc.typeThesis-Reproduction (electronic)
thesis.degree.grantorUniversity of Arizona
thesis.degree.levelmasters
dc.contributor.committeememberWilliams, Stuart
dc.contributor.committeememberGalbraith, David
thesis.degree.disciplineBiomedical Engineering
thesis.degree.nameM.S.
dc.description.noteDigitized from a paper copy provided by the Physiological Sciences Graduate Interdisciplinary Program.
refterms.dateFOA2019-07-06T02:20:41Z


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