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dc.contributor.authorCanales, Robert A
dc.contributor.authorReynolds, Kelly A
dc.contributor.authorWilson, Amanda M
dc.contributor.authorFankem, Sonia L M
dc.contributor.authorWeir, Mark H
dc.contributor.authorRose, Joan B
dc.contributor.authorAbd-Elmaksoud, Sherif
dc.contributor.authorGerba, Charles P
dc.date.accessioned2019-07-17T21:30:30Z
dc.date.available2019-07-17T21:30:30Z
dc.date.issued2019
dc.identifier.citationCanales, R. A., Reynolds, K. A., Wilson, A. M., Fankem, S. L., Weir, M. H., Rose, J. B., ... & Gerba, C. P. (2019). Modeling the role of fomites in a norovirus outbreak. Journal of occupational and environmental hygiene, 16(1), 16-26.en_US
dc.identifier.issn1545-9624
dc.identifier.pmid30274562
dc.identifier.doi10.1080/15459624.2018.1531131
dc.identifier.urihttp://hdl.handle.net/10150/633377
dc.description.abstractNorovirus accounts for a large portion of the gastroenteritis disease burden, and outbreaks have occurred in a wide variety of environments. Understanding the role of fomites in norovirus transmission will inform behavioral interventions, such as hand washing and surface disinfection. The purpose of this study was to estimate the contribution of fomite-mediated exposures to infection and illness risks in outbreaks. A simulation model in discrete time that accounted for hand-to-porous surfaces, hand-to-nonporous surfaces, hand-to-mouth, -eyes, -nose, and hand washing events was used to predict 17 hr of simulated human behavior. Norovirus concentrations originated from monitoring contamination levels on surfaces during an outbreak on houseboats. To predict infection risk, two dose-response models (fractional Poisson and 2F1 hypergeometric) were used to capture a range of infection risks. A triangular distribution describing the conditional probability of illness given an infection was multiplied by modeled infection risks to estimate illness risks. Infection risks ranged from 70.22% to 72.20% and illness risks ranged from 21.29% to 70.36%. A sensitivity analysis revealed that the number of hand-to-mouth contacts and the number of hand washing events had strong relationships with model-predicted doses. Predicted illness risks overlapped with leisure setting and environmental attack rates reported in the literature. In the outbreak associated with the viral concentrations used in this study, attack rates ranged from 50% to 86%. This model suggests that fomites may have accounted for 25% to 82% of illnesses in this outbreak. Fomite-mediated exposures may contribute to a large portion of total attack rates in outbreaks involving multiple transmission modes. The findings of this study reinforce the importance of frequent fomite cleaning and hand washing, especially when ill persons are present.en_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.rights© 2019 JOEH, LLC.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjecthouseboatsen_US
dc.subjectnorovirusen_US
dc.subjectoutbreaken_US
dc.subjectrisk assessmenten_US
dc.subjectfomitesen_US
dc.titleModeling the role of fomites in a norovirus outbreaken_US
dc.typeArticleen_US
dc.identifier.eissn1545-9632
dc.contributor.departmentUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlthen_US
dc.contributor.departmentUniv Arizona, Dept Soil Water & Environm Scien_US
dc.identifier.journalJOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENEen_US
dc.description.note12 month embargo; published online: 04 Feb 2019en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleJournal of occupational and environmental hygiene


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