Authorvan der Pijl, Robbert
AffiliationUniv Arizona, Dept Cellular & Mol Med
MetadataShow full item record
CitationPijl, R., Strom, J., Conijn, S., Lindqvist, J., Labeit, S., Granzier, H., and Ottenheijm, C. ( 2018) Titin‐based mechanosensing modulates muscle hypertrophy. Journal of Cachexia, Sarcopenia and Muscle, 9: 947– 961. https://doi.org/10.1002/jcsm.12319.
Rights© 2018 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractIn wildtype mice, the denervated hemidiaphragm mass increased 48 ± 3% after 6 days of UDD, due to the addition of both sarcomeres in series and in parallel. To test whether titin stiffness modulates the hypertrophy response, RBM20ΔRRM and TtnΔIAjxn mouse models were used, with decreased and increased titin stiffness, respectively. RBM20ΔRRM mice (reduced stiffness) showed a 20 ± 6% attenuated hypertrophy response, whereas the TtnΔIAjxn mice (increased stiffness) showed an 18 ± 8% exaggerated response after UDD. Thus, muscle hypertrophy scales with titin stiffness. Protein expression analysis revealed that titin-binding proteins implicated previously in muscle trophicity were induced during UDD, MARP1 & 2, FHL1, and MuRF1.
NoteOpen access journal
VersionFinal published version
SponsorsNational Institutes of Health [R01HL121500]; MSCA-RISE-2014 project ; Foundation Leducq [13CVD04]
Except where otherwise noted, this item's license is described as © 2018 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License.
- Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.
- Authors: Radke MH, Polack C, Methawasin M, Fink C, Granzier HL, Gotthardt M
- Issue date: 2019 Apr 9
- Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction.
- Authors: Linke WA
- Issue date: 2008 Mar 1
- Comparative decline of the protein profiles of nebulin in response to denervation in skeletal muscle.
- Authors: Wei JH, Chang NC, Chen SP, Geraldine P, Jayakumar T, Fong TH
- Issue date: 2015 Oct 9
- Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction.
- Authors: Methawasin M, Strom JG, Slater RE, Fernandez V, Saripalli C, Granzier H
- Issue date: 2016 Oct 11
- Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function.
- Authors: Unger A, Beckendorf L, Böhme P, Kley R, von Frieling-Salewsky M, Lochmüller H, Schröder R, Fürst DO, Vorgerd M, Linke WA
- Issue date: 2017 Sep 15