Authorvan der Pijl, Robbert
AffiliationUniv Arizona, Dept Cellular & Mol Med
MetadataShow full item record
CitationPijl, R., Strom, J., Conijn, S., Lindqvist, J., Labeit, S., Granzier, H., and Ottenheijm, C. ( 2018) Titin‐based mechanosensing modulates muscle hypertrophy. Journal of Cachexia, Sarcopenia and Muscle, 9: 947– 961. https://doi.org/10.1002/jcsm.12319.
Rights© 2018 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License.
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AbstractIn wildtype mice, the denervated hemidiaphragm mass increased 48 ± 3% after 6 days of UDD, due to the addition of both sarcomeres in series and in parallel. To test whether titin stiffness modulates the hypertrophy response, RBM20ΔRRM and TtnΔIAjxn mouse models were used, with decreased and increased titin stiffness, respectively. RBM20ΔRRM mice (reduced stiffness) showed a 20 ± 6% attenuated hypertrophy response, whereas the TtnΔIAjxn mice (increased stiffness) showed an 18 ± 8% exaggerated response after UDD. Thus, muscle hypertrophy scales with titin stiffness. Protein expression analysis revealed that titin-binding proteins implicated previously in muscle trophicity were induced during UDD, MARP1 & 2, FHL1, and MuRF1.
NoteOpen access journal
VersionFinal published version
SponsorsNational Institutes of Health [R01HL121500]; MSCA-RISE-2014 project ; Foundation Leducq [13CVD04]