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Author
van der Pijl, RobbertStrom, Joshua
Conijn, Stefan
Lindqvist, Johan
Labeit, Siegfried

Granzier, Henk
Ottenheijm, Coen
Affiliation
Univ Arizona, Dept Cellular & Mol MedIssue Date
2018-10
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WILEYCitation
Pijl, R., Strom, J., Conijn, S., Lindqvist, J., Labeit, S., Granzier, H., and Ottenheijm, C. ( 2018) Titin‐based mechanosensing modulates muscle hypertrophy. Journal of Cachexia, Sarcopenia and Muscle, 9: 947– 961. https://doi.org/10.1002/jcsm.12319.Rights
© 2018 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
In wildtype mice, the denervated hemidiaphragm mass increased 48 ± 3% after 6 days of UDD, due to the addition of both sarcomeres in series and in parallel. To test whether titin stiffness modulates the hypertrophy response, RBM20ΔRRM and TtnΔIAjxn mouse models were used, with decreased and increased titin stiffness, respectively. RBM20ΔRRM mice (reduced stiffness) showed a 20 ± 6% attenuated hypertrophy response, whereas the TtnΔIAjxn mice (increased stiffness) showed an 18 ± 8% exaggerated response after UDD. Thus, muscle hypertrophy scales with titin stiffness. Protein expression analysis revealed that titin-binding proteins implicated previously in muscle trophicity were induced during UDD, MARP1 & 2, FHL1, and MuRF1.Note
Open access journalISSN
2190-6009PubMed ID
29978560Version
Final published versionSponsors
National Institutes of Health [R01HL121500]; MSCA-RISE-2014 project [645648]; Foundation Leducq [13CVD04]Additional Links
https://onlinelibrary.wiley.com/doi/full/10.1002/jcsm.12319ae974a485f413a2113503eed53cd6c53
10.1002/jcsm.12319
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Except where otherwise noted, this item's license is described as © 2018 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License.
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