AuthorAsprer, Jeanine Elaine
AffiliationThe University of Arizona College of Medicine – Phoenix
MetadataShow full item record
PublisherThe University of Arizona.
DescriptionA Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.
AbstractOver 21M units of blood are transfused every year, making blood transfusion one of the most common medical interventions in the US. It can be lifesaving, but like many medical interventions, it is not without risks. Thus, most of transfusion research has focused on making the process safer and more accessible. Recent developments in stem cell science – where the transfusion of young blood was shown to reverse stem cell aging and improve physiological function in older mice and conversely, the transfusion of old blood was shown to accelerate stem cell aging and worsen physiological function in younger mice – raise important questions regarding the content of blood being transfused and its associated risks and/or benefits. The purpose of this study is to determine if donor demographics such as age and sex affect patient outcomes. Our hypothesis is that patients receiving blood from younger donors of the same sex have better over-all survival and shorter hospital and ICU stays.