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dc.contributor.authorKassi, Luce Auriane
dc.creatorKassi, Luce Auriane
dc.date.accessioned2019-07-20T02:31:33Z
dc.date.available2019-07-20T02:31:33Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/10150/633435
dc.descriptionA Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.
dc.description.abstractPostpartum hemorrhage (PPH) is the leading cause of maternal death worldwide. Oxytocin is the uterotonic drug of choice to prevent PPH. This systematic review was performed to evaluate the use of misoprostol as a possible alternative in resource-poor settings. Articles were selected on PubMed and the International Journal of Obstetrics and Gynecology based on their primary outcomes (estimated blood loss (EBL) in mL), region (Sub-Saharan Africa) and purpose (comparing (1) misoprostol with oxytocin or with a controlled placebo (2) and different doses of misoprostol). All meta-analyses used a Cohen’s D scale. There was no difference between the use of oxytocin over misoprostol and meta-analysis shows that when used separately, both medications decreased total EBL. Misoprostol at 400 and 600 mcg did not show any difference on EBL compared to oxytocin. In combination with oxytocin, there was no difference on EBL compared to misoprostol alone. When oxytocin was not added to misoprostol, there also was no difference on EBL compared to misoprostol alone. This study suggests that misoprostol may be a sustainable alternative to prevent PPH in resource-poor areas where oxytocin is unavailable.
dc.language.isoen
dc.publisherThe University of Arizona.
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the College of Medicine - Phoenix, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
dc.subjectObstetrics & Gynecology
dc.subjectPostpartum Hemorrhage
dc.subjectMisoprostol
dc.subjectOxytocin
dc.subjectPregnancy
dc.subjectLabor
dc.subject.meshObstetrics
dc.subject.meshGynecology
dc.subject.meshGlobal Health
dc.titleA Systematic Review on the Effect of Misoprostol in the Prevention of Postpartum Hemorrhage in Sub-Saharan African Women of Reproductive Age
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dc.typeElectronic Thesis
dc.contributor.departmentThe University of Arizona College of Medicine – Phoenix
dc.description.collectioninformationThis item is part of the College of Medicine - Phoenix Scholarly Projects 2019 collection. For more information, contact the Phoenix Biomedical Campus Library at pbc-library@email.arizona.edu.
dc.contributor.mentorBrady, Michael
refterms.dateFOA2019-07-20T02:31:33Z


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