A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding
AffiliationUniv Arizona, Dept Neurosci
Univ Arizona, Grad Interdisciplinary Program Neurosci
Univ Arizona, Bio5 Inst
Univ Arizona, Dept Neurol
MetadataShow full item record
PublisherNATURE PUBLISHING GROUP
CitationWang, Y., Kim, J., Schmit, M. B., Cho, T. S., Fang, C., & Cai, H. (2019). A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding. Nature Communications, 10(1), 2769.
Rights© The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractLoss of appetite or anorexia associated with inflammation impairs quality of life and increases morbidity in many diseases. However, the exact neural mechanism that mediates inflammation-associated anorexia is still poorly understood. Here we identified a population of neurons, marked by the expression of protein kinase C-delta, in the oval region of the bed nucleus of the stria terminalis (BNST), which are activated by various inflammatory signals. Silencing of these neurons attenuates the anorexia caused by these inflammatory signals. Our results demonstrate that these neurons mediate bidirectional control of general feeding behaviors. These neurons inhibit the lateral hypothalamus-projecting neurons in the ventrolateral part of BNST to regulate feeding, receive inputs from the canonical feeding regions of arcuate nucleus and parabrachial nucleus. Our data therefore define a BNST microcircuit that might coordinate canonical feeding centers to regulate food intake, which could offer therapeutic targets for feeding-related diseases such as anorexia and obesity.
NoteOpen access journal
VersionFinal published version
SponsorsNARSAD Young Investigator Award from the Brain & Behavior Research Foundation; Bio5 Institute at the University of Arizona
Except where otherwise noted, this item's license is described as © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License.
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