A Subdomain Method for Mapping the Heterogeneous Mechanical Properties of the Human Posterior Sclera
AuthorKollech, Hirut G
Vande Geest, Jonathan P
AffiliationUniv Arizona, Dept Aerosp & Mech Engn
MetadataShow full item record
PublisherFRONTIERS MEDIA SA
CitationVande Geest, J., Kollech, H. G., Ayyalasomayajula, A., Behkam, R., Tamimi, E., Furdella, K., & Drewry, M. (2019). A subdomain method for mapping the heterogeneous mechanical properties of the human posterior sclera. Frontiers in Bioengineering and Biotechnology, 7, 129.
Rights© 2019 Kollech, Ayyalasomayajula, Behkam, Tamimi, Furdella, Drewry and Vande Geest. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractAlthough strongly correlated with elevated intraocular pressure, primary open-angle glaucoma (POAG) occurs in normotensive eyes. Mechanical properties of the sclera around the optic nerve head (ONH) may play a role in this disparity. The purpose of this study is to present an automated inverse mechanics based approach to determine the distribution of heterogeneous mechanical properties of the human sclera as derived from its surface deformations arising from pressure in fl ation experiments. The scleral shell of a 78 year old European Descent male donor eye was utilized to demonstrate the method; the sclera was coated with a speckle pattern on the outer surface and was subjected to in fl ation pressures of 5, 15, 30, and 45 mmHg. The speckle pattern was imaged at each pressure, and a displacement fi eld was calculated for each pressure step using a previously described sequential digital image correlation(S-DIC) technique. The fiber splay and fiber orientation of the sclera collagen were determined experimentally, and the thickness across the scleral globe was determined using micro CT images. The displacement fi eld from the in fl ation test was used to calculate the strain and also used as an input for inverse mechanics to determine the heterogeneity of material properties. The scleral geometry was divided into subdomains using the first principal strain. The Holzapfel anisotropic material parameters of matrix and fiber stiffness were estimated within each individual subdomain using an inverse mechanics approach by minimizing the sum of the square of the residuals between the computational and experimental displacement fields. The mean and maximum error in displacement across all subdomains were 8.9 +/- 3.0 mu m and 13.2 mu m, respectively. The full pressure-inflation forwardmechanics experiment was done using subdomain-specific mechanical properties on the entire scleral surface. The proposed approach is effective in determining the distribution of heterogeneous mechanical properties of the human sclera in a user-independent manner. Our research group is currently utilizing this approach to better elucidate how scleral stiffness influences those at high risk for POAG.
NoteOpen access journal
VersionFinal published version
SponsorsNational Eye Institute of the National Institutes of Health (NIH) [R01EY020890, R01FD006582]; University of Pittsburgh Center for Research Computing (CRC); Pittsburgh Supercomputer Center through NSF-XSEDE award [TG-ENG160035]
- Peripapillary and posterior scleral mechanics--part I: development of an anisotropic hyperelastic constitutive model.
- Authors: Girard MJ, Downs JC, Burgoyne CF, Suh JK
- Issue date: 2009 May
- Glaucoma-related Changes in the Mechanical Properties and Collagen Micro-architecture of the Human Sclera.
- Authors: Coudrillier B, Pijanka JK, Jefferys JL, Goel A, Quigley HA, Boote C, Nguyen TD
- Issue date: 2015
- Peripapillary and posterior scleral mechanics--part II: experimental and inverse finite element characterization.
- Authors: Girard MJ, Downs JC, Bottlang M, Burgoyne CF, Suh JK
- Issue date: 2009 May
- Sequential-digital image correlation for mapping human posterior sclera and optic nerve head deformation.
- Authors: Pyne JD, Genovese K, Casaletto L, Vande Geest JP
- Issue date: 2014 Feb
- The in vitro inflation response of mouse sclera.
- Authors: Myers KM, Cone FE, Quigley HA, Gelman S, Pease ME, Nguyen TD
- Issue date: 2010 Dec