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    CFTR regulates B cell activation and lymphoid follicle development

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    s12931-019-1103-1.pdf
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    Description:
    Final Published Version
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    Author
    Polverino, Francesca
    Lu, Bao
    Quintero, Joselyn Rojas
    Vargas, Sara O
    Patel, Avignat S
    Owen, Caroline A
    Gerard, Norma P
    Gerard, Craig
    Cernadas, Manuela
    Affiliation
    Univ Arizona, Asthma & Airway Dis Res Ctr
    Issue Date
    2019-07-01
    Keywords
    B lymphocyte
    BAFF
    Cystic fibrosis
    Lymphoid follicles
    
    Metadata
    Show full item record
    Publisher
    BMC
    Citation
    Polverino, F., Lu, B., Quintero, J. R., Vargas, S. O., Patel, A. S., Owen, C. A., ... & Cernadas, M. (2019). CFTR regulates B cell activation and lymphoid follicle development. Respiratory research, 20(1), 133.
    Journal
    RESPIRATORY RESEARCH
    Rights
    © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The number of LFs, BAFF+, TLR4+ and proliferation marker Ki67+ B cells in lung explants or resections from subjects with CF and normal controls was quantified by immunostaining. The role of CFTR in B cell activation and LF development was then examined in two independent cohorts of uninfected CFTR-deficient mice (Cftr -/-) and wild type controls. The number of lung LFs, B cells and BAFF+, CXCR4+, immunoglobulin G+ B cells was examined by immunostaining. Lung and splenocyte B cell activation marker and major histocompatibility complex class II (MHC class II) expression was quantified by flow cytometry. Inflammatory cytokine levels were measured in supernatants from isolated B cells from Cftr -/- and wild type mice stimulated in vitro with Pseudomonas aeruginosa lipopolysaccharide (LPS).
    Note
    Open access journal
    ISSN
    1465-993X
    EISSN
    1465-9921
    PubMed ID
    31262295
    DOI
    10.1186/s12931-019-1103-1
    Version
    Final published version
    Sponsors
    CT/MA Cystic Fibrosis/Multiple Sclerosis Fund; May Family Trust; CF Foundation [DRUMMR0, DRUMMR1]
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12931-019-1103-1
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    UA Faculty Publications

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