• Login
    View Item 
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Efficacy of Low Dose Chemoprophylaxis for Coccidioidomycosis Infection in Liver Transplant Recipients

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    1182-8484-1-PB.pdf
    Size:
    1.918Mb
    Format:
    PDF
    Description:
    Final Published Version
    Download
    Author
    Habib, Shahid
    El Ramahi, Razan A
    Rosen, Scott
    Farran, Sumaya
    Shubeilat, Jamilah
    Walker, Courtney
    Casal, Mariana
    Zangeneh, Tirdad
    Affiliation
    Univ Arizona, Banner Univ, Med Ctr
    Issue Date
    2019-06
    Keywords
    Coccidioidomycosis
    Fungal infection
    Liver transplant
    Prophylaxis
    
    Metadata
    Show full item record
    Publisher
    ELMER PRESS INC
    Citation
    Habib, S., El Ramahi, R. A., Rosen, S., Farran, S., Shubeilat, J., Walker, C., ... & Zangeneh, T. (2019). Efficacy of Low Dose Chemoprophylaxis for Coccidioidomycosis Infection in Liver Transplant Recipients. Gastroenterology Research, 12(3), 148.
    Journal
    GASTROENTEROLOGY RESEARCH
    Rights
    © The authors © Gastroenterol Res and Elmer Press Inc™ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Background: Coccidioidomycosis (CM) infections among transplant recipients result in significant morbidity and mortality. The goal of our study was to establish the efficacy of low dose (LD) versus standard dose (LD, 50 mg daily) fluconazole in preventing CM infection. Methods: This was a retrospective study utilizing electronic medical records of liver transplant recipients at the University of Arizona. The primary end point was post-transplant CM status, such as infection, complications and survival. Results: We detected a statistically significant correlation between positive pre-transplant status and positive post-transplant status (hazards ratio: 8.25 (95% confidence interval: 1.028 - 66.192)). There was a trend towards improved survival in patients who had a positive post-transplant CM status in the SD group versus LD group (90.9% versus 81.3%), although not statistically significant. Conclusion: The risk of CM infection among transplant recipients in the absence of prophylaxis is associated with high morbidity and mortality. We currently use SD fluconazole as universal prophylaxis in all transplant recipients despite not establishing statistical significance between LD and SD. We believe that the survival trend detected may have not reached statistical significance due to low power impact. Since the standardization of SD prophylaxis at our institution, we have not diagnosed further new post-transplant CM infections.
    Note
    Open access journal
    ISSN
    1918-2805
    EISSN
    1918-2813
    PubMed ID
    31236156
    DOI
    10.14740/gr1182
    Version
    Final published version
    ae974a485f413a2113503eed53cd6c53
    10.14740/gr1182
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

    Related articles

    • Universal fungal prophylaxis and risk of coccidioidomycosis in liver transplant recipients living in an endemic area.
    • Authors: Kahn A, Carey EJ, Blair JE
    • Issue date: 2015 Mar
    • Early results of targeted prophylaxis for coccidioidomycosis in patients undergoing orthotopic liver transplantation within an endemic area.
    • Authors: Blair JE, Douglas DD, Mulligan DC
    • Issue date: 2003 Mar
    • Single-center experience of antifungal prophylaxis for coccidioidomycosis in heart transplant recipients within an endemic area.
    • Authors: Lohrmann GM, Vucicevic D, Lawrence R, Steidley DE, Scott RL, Kusne S, Blair JE
    • Issue date: 2017 Oct
    • Randomized, double-blind trial of anidulafungin versus fluconazole for prophylaxis of invasive fungal infections in high-risk liver transplant recipients.
    • Authors: Winston DJ, Limaye AP, Pelletier S, Safdar N, Morris MI, Meneses K, Busuttil RW, Singh N
    • Issue date: 2014 Dec
    • Coccidioidomycosis in liver transplant recipients relocating to an endemic area.
    • Authors: Blair JE, Douglas DD
    • Issue date: 2004 Nov-Dec
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.