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dc.contributor.authorHabib, Shahid
dc.contributor.authorEl Ramahi, Razan A
dc.contributor.authorRosen, Scott
dc.contributor.authorFarran, Sumaya
dc.contributor.authorShubeilat, Jamilah
dc.contributor.authorWalker, Courtney
dc.contributor.authorCasal, Mariana
dc.contributor.authorZangeneh, Tirdad
dc.date.accessioned2019-08-01T22:15:22Z
dc.date.available2019-08-01T22:15:22Z
dc.date.issued2019-06
dc.identifier.citationHabib, S., El Ramahi, R. A., Rosen, S., Farran, S., Shubeilat, J., Walker, C., ... & Zangeneh, T. (2019). Efficacy of Low Dose Chemoprophylaxis for Coccidioidomycosis Infection in Liver Transplant Recipients. Gastroenterology Research, 12(3), 148.en_US
dc.identifier.issn1918-2805
dc.identifier.pmid31236156
dc.identifier.doi10.14740/gr1182
dc.identifier.urihttp://hdl.handle.net/10150/633626
dc.description.abstractBackground: Coccidioidomycosis (CM) infections among transplant recipients result in significant morbidity and mortality. The goal of our study was to establish the efficacy of low dose (LD) versus standard dose (LD, 50 mg daily) fluconazole in preventing CM infection. Methods: This was a retrospective study utilizing electronic medical records of liver transplant recipients at the University of Arizona. The primary end point was post-transplant CM status, such as infection, complications and survival. Results: We detected a statistically significant correlation between positive pre-transplant status and positive post-transplant status (hazards ratio: 8.25 (95% confidence interval: 1.028 - 66.192)). There was a trend towards improved survival in patients who had a positive post-transplant CM status in the SD group versus LD group (90.9% versus 81.3%), although not statistically significant. Conclusion: The risk of CM infection among transplant recipients in the absence of prophylaxis is associated with high morbidity and mortality. We currently use SD fluconazole as universal prophylaxis in all transplant recipients despite not establishing statistical significance between LD and SD. We believe that the survival trend detected may have not reached statistical significance due to low power impact. Since the standardization of SD prophylaxis at our institution, we have not diagnosed further new post-transplant CM infections.en_US
dc.language.isoenen_US
dc.publisherELMER PRESS INCen_US
dc.rights© The authors © Gastroenterol Res and Elmer Press Inc™ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectCoccidioidomycosisen_US
dc.subjectFungal infectionen_US
dc.subjectLiver transplanten_US
dc.subjectProphylaxisen_US
dc.titleEfficacy of Low Dose Chemoprophylaxis for Coccidioidomycosis Infection in Liver Transplant Recipientsen_US
dc.typeArticleen_US
dc.identifier.eissn1918-2813
dc.contributor.departmentUniv Arizona, Banner Univ, Med Ctren_US
dc.identifier.journalGASTROENTEROLOGY RESEARCHen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleGastroenterology research
refterms.dateFOA2019-08-01T22:15:22Z


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