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dc.contributor.authorYuan, Cai
dc.contributor.authorWang, Zhonghai
dc.contributor.authorBorg, Thomas K.
dc.contributor.authorYe, Tong
dc.contributor.authorBaicu, Catalin
dc.contributor.authorBradshaw, Amy
dc.contributor.authorZile, Michael
dc.contributor.authorRunyan, Raymond B.
dc.contributor.authorShao, Yonghong
dc.contributor.authorGao, Bruce Z.
dc.date.accessioned2019-08-06T17:01:54Z
dc.date.available2019-08-06T17:01:54Z
dc.date.issued2019-06-07
dc.identifier.citationYuan, C., Wang, Z., Borg, T. K., Ye, T., Baicu, C., Bradshaw, A., ... & Gao, B. Z. (2019). Changes in the crystallographic structures of cardiac myosin filaments detected by polarization-dependent second harmonic generation microscopy. Biomedical Optics Express, 10(7), 3183-3195.en_US
dc.identifier.issn2156-7085
dc.identifier.doi10.1364/boe.10.003183
dc.identifier.urihttp://hdl.handle.net/10150/633692
dc.description.abstractDetecting the structural changes caused by volume and pressure overload is critical to comprehending the mechanisms of physiologic and pathologic hypertrophy. This study explores the structural changes at the crystallographic level in myosin filaments in volume- and pressure-overloaded myocardia through polarization-dependent second harmonic generation microscopy. Here, for the first time, we report that the ratio of nonlinear susceptibility tensor components d33/d15 increased significantly in volume- and pressure-overloaded myocardial tissues compared with the ratio in normal mouse myocardial tissues. Through cell stretch experiments, we demonstrated that mechanical tension plays an important role in the increase of d33/d15 in volume- and pressure-overloaded myocardial tissues.en_US
dc.description.sponsorshipNational Institutes of Health through SC COBRE [P20RR021949, P20GM130451]; National Science Foundation EPSCoR Program [OIA-1655740]; National Natural Science Foundation of China [61775148]; [R01HL124782]; [R01HL144927]en_US
dc.language.isoenen_US
dc.publisherThe Optical Societyen_US
dc.rightsCopyright © 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreementen_US
dc.titleChanges in the crystallographic structures of cardiac myosin filaments detected by polarization-dependent second harmonic generation microscopyen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Cell Biol & Anatontyen_US
dc.identifier.journalBIOMEDICAL OPTICS EXPRESSen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.volume10
dc.source.issue7
dc.source.beginpage3183
refterms.dateFOA2019-08-06T17:01:54Z


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