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    RpoN and the Nps and Npa two-component regulatory system control pilE transcription in commensal Neisseria

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    Name:
    Rend-n_et_al-2019-Microbiology ...
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    Author
    Rendón, María A
    Lona, Beatriz
    Ma, Mancheong
    So, Magdalene cc
    Affiliation
    Univ Arizona, BIO5 Inst
    Univ Arizona, Dept Immunobiol
    Issue Date
    2019-05
    Keywords
    Neisseria
    Type IV fimbriae
    transcription regulation
    two-component sensors
    
    Metadata
    Show full item record
    Publisher
    WILEY
    Citation
    Rendón, M. A., Lona, B., Ma, M., & So, M. (2019). RpoN and the Nps and Npa two‐component regulatory system control pilE transcription in commensal Neisseria. MicrobiologyOpen, e00713.
    Journal
    MICROBIOLOGYOPEN
    Rights
    © 2018 The Authors. Microbiology Open published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Over 20 genes are involved in the biogenesis and function of the Neisseria Type IV pilus (Tfp). In the pathogenic species, RpoD and the integration host factor (IHF) protein regulate expression of pilE, encoding the Tfp structural subunit. We previously reported that in commensal species, pilE transcription is regulated by RpoN, IHF, and activator Npa. Npa has many hallmarks of response regulators in two-component regulatory systems, leading us to search for its response regulator partner. We report that Npa partners with sensor kinase Nps to control pilE transcription. Among the genes involved in Tfp biogenesis and function, only pilE is controlled by RpoN and Npa/Nps. We summarize our findings in a model, and discuss the implications of the differential regulation of pilE the context of Neisseria Tfp biogenesis.
    Note
    Open access journal
    ISSN
    2045-8827
    PubMed ID
    30079633
    DOI
    10.1002/mbo3.713
    Version
    Final published version
    Sponsors
    National Institutes of Health [R01AI107966]
    ae974a485f413a2113503eed53cd6c53
    10.1002/mbo3.713
    Scopus Count
    Collections
    UA Faculty Publications

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