RpoN and the Nps and Npa two-component regulatory system control pilE transcription in commensal Neisseria
AffiliationUniv Arizona, BIO5 Inst
Univ Arizona, Dept Immunobiol
MetadataShow full item record
CitationRendón, M. A., Lona, B., Ma, M., & So, M. (2019). RpoN and the Nps and Npa two‐component regulatory system control pilE transcription in commensal Neisseria. MicrobiologyOpen, e00713.
Rights© 2018 The Authors. Microbiology Open published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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AbstractOver 20 genes are involved in the biogenesis and function of the Neisseria Type IV pilus (Tfp). In the pathogenic species, RpoD and the integration host factor (IHF) protein regulate expression of pilE, encoding the Tfp structural subunit. We previously reported that in commensal species, pilE transcription is regulated by RpoN, IHF, and activator Npa. Npa has many hallmarks of response regulators in two-component regulatory systems, leading us to search for its response regulator partner. We report that Npa partners with sensor kinase Nps to control pilE transcription. Among the genes involved in Tfp biogenesis and function, only pilE is controlled by RpoN and Npa/Nps. We summarize our findings in a model, and discuss the implications of the differential regulation of pilE the context of Neisseria Tfp biogenesis.
NoteOpen access journal
VersionFinal published version
SponsorsNational Institutes of Health [R01AI107966]