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dc.contributor.authorRendón, María A
dc.contributor.authorLona, Beatriz
dc.contributor.authorMa, Mancheong
dc.contributor.authorSo, Magdalene
dc.date.accessioned2019-08-08T23:04:03Z
dc.date.available2019-08-08T23:04:03Z
dc.date.issued2019-05
dc.identifier.citationRendón, M. A., Lona, B., Ma, M., & So, M. (2019). RpoN and the Nps and Npa two‐component regulatory system control pilE transcription in commensal Neisseria. MicrobiologyOpen, e00713.en_US
dc.identifier.issn2045-8827
dc.identifier.pmid30079633
dc.identifier.doi10.1002/mbo3.713
dc.identifier.urihttp://hdl.handle.net/10150/633769
dc.description.abstractOver 20 genes are involved in the biogenesis and function of the Neisseria Type IV pilus (Tfp). In the pathogenic species, RpoD and the integration host factor (IHF) protein regulate expression of pilE, encoding the Tfp structural subunit. We previously reported that in commensal species, pilE transcription is regulated by RpoN, IHF, and activator Npa. Npa has many hallmarks of response regulators in two-component regulatory systems, leading us to search for its response regulator partner. We report that Npa partners with sensor kinase Nps to control pilE transcription. Among the genes involved in Tfp biogenesis and function, only pilE is controlled by RpoN and Npa/Nps. We summarize our findings in a model, and discuss the implications of the differential regulation of pilE the context of Neisseria Tfp biogenesis.en_US
dc.description.sponsorshipNational Institutes of Health [R01AI107966]en_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.rights© 2018 The Authors. Microbiology Open published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectNeisseriaen_US
dc.subjectType IV fimbriaeen_US
dc.subjecttranscription regulationen_US
dc.subjecttwo-component sensorsen_US
dc.titleRpoN and the Nps and Npa two-component regulatory system control pilE transcription in commensal Neisseriaen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, BIO5 Insten_US
dc.contributor.departmentUniv Arizona, Dept Immunobiolen_US
dc.identifier.journalMICROBIOLOGYOPENen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleMicrobiologyOpen
refterms.dateFOA2019-08-08T23:04:03Z


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