Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species
AuthorBubier, Jason A
Sutphin, George L
Reynolds, Timothy J
Baker, Erich J
Langston, Michael A
Chesler, Elissa J
AffiliationUniv Arizona, Mol & Cellular Biol
MetadataShow full item record
PublisherPUBLIC LIBRARY SCIENCE
CitationBubier JA, Sutphin GL, Reynolds TJ, Korstanje R, Fuksman-Kumpa A, Baker EJ, et al. (2019) Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species. PLoS ONE 14(4): e0214523. https://doi.org/10.1371/journal.pone.0214523
Rights© 2019 Bubier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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AbstractUnderstanding the biological mechanisms behind aging, lifespan and healthspan is becoming increasingly important as the proportion of the world's population over the age of 65 grows, along with the cost and complexity of their care. BigData oriented approaches and analysis methods enable current and future bio-gerontologists to synthesize, distill and interpret vast, heterogeneous data from functional genomics studies of aging. GeneWeaver is an analysis system for integration of data that allows investigators to store, search, and analyze immense amounts of data including user-submitted experimental data, data from primary publications, and data in other databases. Aging related genome-wide gene sets from primary publications were curated into this system in concert with data from other model-organism and aging-specific databases, and applied to several questions in genrontology using. For example, we identified Cd63 as a frequently represented gene among aging-related genome-wide results. To evaluate the role of Cd63 in aging, we performed RNAi knockdown of the C. elegans ortholog, tsp-7, demonstrating that this manipulation is capable of extending lifespan. The tools in GeneWeaver enable aging researchers to make new discoveries into the associations between the genes, normal biological processes, and diseases that affect aging, healthspan, and lifespan.
NoteOpen access journal.
VersionFinal published version
SponsorsNathan Shock Center of Excellence on the Biology of Aging [AG038070]; National Institute of Drug Abuse [AA018776]
- GeneWeaver: finding consilience in heterogeneous cross-species functional genomics data.
- Authors: Bubier JA, Phillips CA, Langston MA, Baker EJ, Chesler EJ
- Issue date: 2015 Oct
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- Authors: Jay JJ, Chesler EJ
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