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dc.contributor.authorLiou, Theodore G.
dc.contributor.authorAdler, Frederick R.
dc.contributor.authorArgel, Natalia
dc.contributor.authorAsfour, Fadi
dc.contributor.authorBrown, Perry S.
dc.contributor.authorChatfield, Barbara A.
dc.contributor.authorDaines, Cori L.
dc.contributor.authorDurham, Dixie
dc.contributor.authorFrancis, Jessica A.
dc.contributor.authorGlover, Barbara
dc.contributor.authorHeynekamp, Theresa
dc.contributor.authorHoidal, John R.
dc.contributor.authorJensen, Judy L.
dc.contributor.authorKeogh, Ruth
dc.contributor.authorKopecky, Carol M.
dc.contributor.authorLechtzin, Noah
dc.contributor.authorLi, Yanping
dc.contributor.authorLysinger, Jerimiah
dc.contributor.authorMolina, Osmara
dc.contributor.authorNakamura, Craig
dc.contributor.authorPacker, Kristyn A.
dc.contributor.authorPoch, Katie R.
dc.contributor.authorQuittner, Alexandra L.
dc.contributor.authorRadford, Peggy
dc.contributor.authorRedway, Abby J.
dc.contributor.authorSagel, Scott D.
dc.contributor.authorSprandel, Shawna
dc.contributor.authorTaylor-Cousar, Jennifer L.
dc.contributor.authorVroom, Jane B.
dc.contributor.authorYoshikawa, Ryan
dc.contributor.authorClancy, John P.
dc.contributor.authorElborn, J. Stuart
dc.contributor.authorOlivier, Kenneth N.
dc.contributor.authorCox, David R.
dc.date.accessioned2019-08-19T20:44:38Z
dc.date.available2019-08-19T20:44:38Z
dc.date.issued2019-04-26
dc.identifier.citationLiou, T. G., Adler, F. R., Argel, N., Asfour, F., Brown, P. S., Chatfield, B. A., ... & Heynekamp, T. (2019). Prospective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis. BMC medical research methodology, 19(1), 88.en_US
dc.identifier.issn1471-2288
dc.identifier.pmid31027503
dc.identifier.doi10.1186/s12874-019-0705-0
dc.identifier.urihttp://hdl.handle.net/10150/633874
dc.description.abstractBackground: Biomarkers of inflammation predictive of cystic fibrosis (CF) disease outcomes would increase the power of clinical trials and contribute to better personalization of clinical assessments. A representative patient cohort would improve searching for believable, generalizable, reproducible and accurate biomarkers. Methods: We recruited patients from Mountain West CF Consortium (MWCFC) care centers for prospective observational study of sputum biomarkers of inflammation. After informed consent, centers enrolled randomly selected patients with CF who were clinically stable sputum producers, 12years of age and older, without previous organ transplantation. Results: From December 8, 2014 through January 16, 2016, we enrolled 114 patients (53 male) with CF with continuing data collection. Baseline characteristics included mean age 27 years (SD = 12), 80% predicted forced expiratory volume in 1s (SD = 23%), 1.0 prior year pulmonary exacerbations (SD = 1.2), home elevation 328 m (SD=112) above sea level. Compared with other patients in the US CF Foundation Patient Registry (CFFPR) in 2014, MWCFC patients had similar distribution of sex, age, lung function, weight and rates of exacerbations, diabetes, pancreatic insufficiency, CF-related arthropathy and airway infections including methicillin-sensitive or -resistant Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia complex, fungal and non-tuberculous Mycobacteria infections. They received CF-specific treatments at similar frequencies. Conclusions: Randomly-selected, sputum-producing patients within the MWCFC represent sputum-producing patients in the CFFPR. They have similar characteristics, lung function and frequencies of pulmonary exacerbations, microbial infections and use of CF-specific treatments. These findings will plausibly make future interpretations of quantitative measurements of inflammatory biomarkers generalizable to sputum-producing patients in the CFFPR.en_US
dc.description.sponsorshipCF Foundation (CFF) [LIOU13A0, LIOU14Y4]; National Center for Advancing Translational Science at the National Institutes of Health [NCATS/NIH 8UL1TR000105]; Ben B and Iris M Margolis Foundation of Utah; Claudia Ruth Goodrich Stevens Endowment Funden_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.rightsCopyright © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCystic fibrosisen_US
dc.subjectRandomized observational trialen_US
dc.subjectStudy designen_US
dc.subjectSputum inflammationen_US
dc.subjectHMGB-1en_US
dc.subjectNeutrophil elastaseen_US
dc.subjectCalprotectinen_US
dc.subjectCystic Fibrosis Foundation patient registryen_US
dc.titleProspective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosisen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona Hlth Scien_US
dc.identifier.journalBMC MEDICAL RESEARCH METHODOLOGYen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.volume19
dc.source.issue1
refterms.dateFOA2019-08-19T20:44:39Z


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Copyright © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Except where otherwise noted, this item's license is described as Copyright © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.