Evolution of Hominin Polyunsaturated Fatty Acid Metabolism: From Africa to the New World
AuthorHarris, Daniel N
Yanek, Lisa R
Becker, Lewis C
Becker, Diane M
Chilton, Floyd H
Mathias, Rasika A
O'Connor, Timothy D
AffiliationUniv Arizona, Dept Nutr Sci
MetadataShow full item record
PublisherOXFORD UNIV PRESS
CitationN Harris, Daniel & Ruczinski, Ingo & Yanek, Lisa & C Becker, Lewis & Becker, Diane & Guio, Heinner & Cui, Tao & Chilton, Floyd & A Mathias, Rasika & D O'Connor, Timothy. (2019). Evolution of Hominin Polyunsaturated Fatty Acid Metabolism: From Africa to the New World. Genome biology and evolution. 11. 10.1093/gbe/evz071.
JournalGENOME BIOLOGY AND EVOLUTION
RightsCopyright © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractThe metabolic conversion of dietary omega-3 and omega-6 18 carbon (18C) to long chain (>20 carbon) polyunsaturated fatty acids (LC-PUFAs) is vital for human life. The rate-limiting steps of this process are catalyzed by fatty acid desaturase (FADS) 1 and 2. Therefore, understanding the evolutionary history of the FADS genes is essential to our understanding of hominin evolution. The FADS genes have two haplogroups, ancestral and derived, with the derived haplogroup being associated with more efficient LC-PUFA biosynthesis than the ancestral haplogroup. In addition, there is a complex global distribution of these haplogroups that is suggestive of Neanderthal introgression. We confirm that Native American ancestry is nearly fixed for the ancestral haplogroup, and replicate a positive selection signal in Native Americans. This positive selection potentially continued after the founding of the Americas, although simulations suggest that the timing is dependent on the allele frequency of the ancestral Beringian population. We also find that the Neanderthal FADS haplotype is more closely related to the derived haplogroup and the Denisovan clusters closer to the ancestral haplogroup. Furthermore, the derived haplogroup has a time to the most recent common ancestor of 688,474years before present. These results support an ancient polymorphism, as opposed to Neanderthal introgression, forming in the FADS region during the Pleistocene with possibly differential selection pressures on both haplogroups. The near fixation of the ancestral haplogroup in Native American ancestry calls for future studies to explore the potential health risk of associated low LC-PUFA levels in these populations.
NoteOpen access journal
VersionFinal published version
SponsorsCenter for Health Related Informatics and Biomaging at the University of Maryland School of Medicine; National Institutes of Health/National Heart, Lung, and Blood Institute [U01 HL72518, HL087698, HL112064]; National Institutes of Health [R01-AT008621]
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