Chronic antibiotic use during adulthood and weight change in the Sister Study
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Univ Arizona, Dept Commun Environm & PolicyIssue Date
2019-05-16
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PUBLIC LIBRARY SCIENCECitation
Furlong M, Deming-Halverson S, Sandler DP (2019) Chronic antibiotic use during adulthood and weight change in the Sister Study. PLoS ONE 14(5): e0216959. https://doi.org/10.1371/journal.pone.0216959Journal
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This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Background/Objectives: Antibiotic use in early life has been associated with weight gain in several populations. However, associations between chronic antibiotic use and weight among adults in the general population are unknown. Subjects/Methods: The NIEHS Sister Study is a longitudinal cohort of sisters of women with breast cancer. We examined associations between chronic antibiotic use (>= 3 months) during the fourth decade of life (30-39 years) and subsequent obesity at enrollment (mean age = 55) via logistic regression. We also examined associations between chronic antibiotic use in the 5 years and 12 months prior to enrollment and weight gain after enrollment in linear mixed models. Models were adjusted for race/ethnicity, education, urban/rural status, age, and smoking. Results: In adjusted analyses (n = 50,237), chronic penicillin use during the 4 th decade of life was associated with obesity at enrollment (OR 2.00, 95% CI 1.40, 2.87), and use in the 5 years prior to enrollment was associated with increased BMI change after enrollment (beta 1.00 95% CI 0.01, 2.00). Use of bactericidals (OR 1.71, 95% CI 1.29, 2.26) during the 4 th decade of life was also associated with obesity at enrollment. Associations for penicillins and bactericidals were consistent across indications for use. Bacteriostatic use in the 5 years prior to enrollment was associated with a reduction in BMI after enrollment (beta -0.52, 95% CI -1.04, 0.00), and tetracycline use during the 4 th decade of life was associated with reduced odds of obesity at enrollment (OR 0.72, 95% CI 0.56, 0.92). However, these inverse associations were only present for those who reported taking antibiotics for skin purposes. Cephalosporins, macrolides, quinolones, and sulfonamides were not associated with BMI change over time. Conclusions: Chronic use of antibiotics during adulthood may have long-lasting impacts on BMI. Associations may differ by antibiotic class, and confounding by indication may be important for some antibiotic classes.Note
Open access journalISSN
1932-6203PubMed ID
31095628Version
Final published versionSponsors
Intramural Research Program of the NIH, National Institute of Environmental Sciences [Z01ES044005]; NIEHS [T32ES007018, K99ES028743]; NIHae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0216959