Chronic antibiotic use during adulthood and weight change in the Sister Study
AffiliationUniv Arizona, Dept Commun Environm & Policy
MetadataShow full item record
PublisherPUBLIC LIBRARY SCIENCE
CitationFurlong M, Deming-Halverson S, Sandler DP (2019) Chronic antibiotic use during adulthood and weight change in the Sister Study. PLoS ONE 14(5): e0216959. https://doi.org/10.1371/journal.pone.0216959
RightsThis is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractBackground/Objectives: Antibiotic use in early life has been associated with weight gain in several populations. However, associations between chronic antibiotic use and weight among adults in the general population are unknown. Subjects/Methods: The NIEHS Sister Study is a longitudinal cohort of sisters of women with breast cancer. We examined associations between chronic antibiotic use (>= 3 months) during the fourth decade of life (30-39 years) and subsequent obesity at enrollment (mean age = 55) via logistic regression. We also examined associations between chronic antibiotic use in the 5 years and 12 months prior to enrollment and weight gain after enrollment in linear mixed models. Models were adjusted for race/ethnicity, education, urban/rural status, age, and smoking. Results: In adjusted analyses (n = 50,237), chronic penicillin use during the 4 th decade of life was associated with obesity at enrollment (OR 2.00, 95% CI 1.40, 2.87), and use in the 5 years prior to enrollment was associated with increased BMI change after enrollment (beta 1.00 95% CI 0.01, 2.00). Use of bactericidals (OR 1.71, 95% CI 1.29, 2.26) during the 4 th decade of life was also associated with obesity at enrollment. Associations for penicillins and bactericidals were consistent across indications for use. Bacteriostatic use in the 5 years prior to enrollment was associated with a reduction in BMI after enrollment (beta -0.52, 95% CI -1.04, 0.00), and tetracycline use during the 4 th decade of life was associated with reduced odds of obesity at enrollment (OR 0.72, 95% CI 0.56, 0.92). However, these inverse associations were only present for those who reported taking antibiotics for skin purposes. Cephalosporins, macrolides, quinolones, and sulfonamides were not associated with BMI change over time. Conclusions: Chronic use of antibiotics during adulthood may have long-lasting impacts on BMI. Associations may differ by antibiotic class, and confounding by indication may be important for some antibiotic classes.
NoteOpen access journal
VersionFinal published version
SponsorsIntramural Research Program of the NIH, National Institute of Environmental Sciences [Z01ES044005]; NIEHS [T32ES007018, K99ES028743]; NIH
- Antibiotic use and childhood body mass index trajectory.
- Authors: Schwartz BS, Pollak J, Bailey-Davis L, Hirsch AG, Cosgrove SE, Nau C, Kress AM, Glass TA, Bandeen-Roche K
- Issue date: 2016 Apr
- Body weight in early adulthood, adult weight gain, and risk of endometrial cancer in women not using postmenopausal hormones.
- Authors: Stevens VL, Jacobs EJ, Patel AV, Sun J, Gapstur SM, McCullough ML
- Issue date: 2014 Mar
- Associations of weight, weight change, and body mass with breast cancer risk in Hispanic and non-Hispanic white women.
- Authors: Wenten M, Gilliland FD, Baumgartner K, Samet JM
- Issue date: 2002 Aug
- Associations of Weight Gain From Early to Middle Adulthood With Major Health Outcomes Later in Life.
- Authors: Zheng Y, Manson JE, Yuan C, Liang MH, Grodstein F, Stampfer MJ, Willett WC, Hu FB
- Issue date: 2017 Jul 18
- Early Antibiotic Exposure in Low-resource Settings Is Associated With Increased Weight in the First Two Years of Life.
- Authors: Rogawski ET, Platts-Mills JA, Seidman JC, John S, Mahfuz M, Ulak M, Shrestha S, Soofi SB, Yori PP, Mduma E, Svensen E, Ahmed T, Lima AAM, Bhutta Z, Kosek M, Lang D, Gottlieb M, Zaidi A, Kang G, Bessong P, Houpt ER, Guerrant RL, MAL-ED Network Investigators.
- Issue date: 2017 Sep