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dc.contributor.authorChewcharat, Api
dc.contributor.authorThongprayoon, Charat
dc.contributor.authorBathini, Tarun
dc.contributor.authorAeddula, Narothama Reddy
dc.contributor.authorBoonpheng, Boonphiphop
dc.contributor.authorKaewput, Wisit
dc.contributor.authorWatthanasuntorn, Kanramon
dc.contributor.authorLertjitbanjong, Ploypin
dc.contributor.authorSharma, Konika
dc.contributor.authorTorres-Ortiz, Aldo
dc.contributor.authorLeeaphorn, Napat
dc.contributor.authorMao, Michael A
dc.contributor.authorKhoury, Nadeen J
dc.contributor.authorCheungpasitporn, Wisit
dc.date.accessioned2019-08-28T19:42:47Z
dc.date.available2019-08-28T19:42:47Z
dc.date.issued2019-04
dc.identifier.citationChewcharat, A.; Thongprayoon, C.; Bathini, T.; Aeddula, N.R.; Boonpheng, B.; Kaewput, W.; Watthanasuntorn, K.; Lertjitbanjong, P.; Sharma, K.; Torres-Ortiz, A.; Leeaphorn, N.; Mao, M.A.; Khoury, N.J.; Cheungpasitporn, W. Incidence and Mortality of Renal Cell Carcinoma after Kidney Transplantation: A Meta-Analysis. J. Clin. Med. 2019, 8, 530.en_US
dc.identifier.issn2077-0383
dc.identifier.pmid30999706
dc.identifier.doi10.3390/jcm8040530
dc.identifier.urihttp://hdl.handle.net/10150/634018
dc.description.abstractBackground: The incidence and mortality of renal cell carcinoma (RCC) after kidney transplantation (KTx) remain unclear. This study's aims were (1) to investigate the pooled incidence/incidence trends, and (2) to assess the mortality/mortality trends in KTx patients with RCC. Methods: A literature search was conducted using the MEDLINE, EMBASE and Cochrane databases from inception through October 2018. Studies that reported the incidence or mortality of RCC among kidney transplant recipients were included. The pooled incidence and 95% CI were calculated using a random-effect model. The protocol for this meta-analysis is registered with PROSPERO; no. CRD42018108994. Results: A total of 22 observational studies with a total of 320,190 KTx patients were enrolled. Overall, the pooled estimated incidence of RCC after KTx was 0.7% (95% CI: 0.5-0.8%, I-2 = 93%). While the pooled estimated incidence of de novo RCC in the native kidney was 0.7% (95% CI: 0.6-0.9%, I-2 = 88%), the pooled estimated incidence of RCC in the allograft kidney was 0.2% (95% CI: 0.1-0.4%, I-2 = 64%). The pooled estimated mortality rate in KTx recipients with RCC was 15.0% (95% CI: 7.4-28.1%, I-2 = 80%) at a mean follow-up time of 42 months after RCC diagnosis. While meta-regression analysis showed a significant negative correlation between year of study and incidence of de novo RCC post-KTx (slopes = -0.05, p = 0.01), there were no significant correlations between the year of study and mortality of patients with RCC (p = 0.50). Egger's regression asymmetry test was performed and showed no publication bias in all analyses. Conclusions: The overall estimated incidence of RCC after KTX was 0.7%. Although there has been a potential decrease in the incidence of RCC post-KTx, mortality in KTx patients with RCC has not decreased over time.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectkidney transplantationen_US
dc.subjectmalignancyen_US
dc.subjectmeta-analysisen_US
dc.subjectpost-transplant malignancyen_US
dc.subjectrenal cell carcinomaen_US
dc.subjectsystematic reviewsen_US
dc.subjecttransplantationen_US
dc.titleIncidence and Mortality of Renal Cell Carcinoma after Kidney Transplantation: A Meta-Analysisen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Internal Meden_US
dc.identifier.journalJOURNAL OF CLINICAL MEDICINEen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleJournal of clinical medicine
refterms.dateFOA2019-08-28T19:42:47Z


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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).