Adjuvant Therapy for Resected Biliary Tract Cancer: ASCO Clinical Practice Guideline
AuthorShroff, Rachna T
Kennedy, Erin B
Katz, Matthew H G
Soares, Heloisa P
Maithel, Shishir K
AffiliationUniv Arizona, Ctr Canc
MetadataShow full item record
PublisherAMER SOC CLINICAL ONCOLOGY
CitationDOI: 10.1200/JCO.18.02178 Journal of Clinical Oncology 37, no. 12 (April 20, 2019) 1015-1027.
JournalJOURNAL OF CLINICAL ONCOLOGY
Rights© 2019 American Society of Clinical Oncology. All rights reserved.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractPURPOSE: To develop an evidence-based clinical practice guideline to assist in clinical decision making for patients with resected biliary tract cancer. METHODS: ASCO convened an Expert Panel to conduct a systematic review of the literature on adjuvant therapy for resected biliary tract cancer and provide recommended care options for this patient population. RESULTS: Three phase III randomized controlled trials, one phase II trial, and 16 retrospective studies met the inclusion criteria. RECOMMENDATIONS: Based on evidence from a phase III randomized controlled trial, patients with resected biliary tract cancer should be offered adjuvant capecitabine chemotherapy for a duration of 6 months. The dosing used in this trial is described in the qualifying statements, while it should be noted that the dose of capecitabine may also be determined by institutional and regional practices. Patients with extrahepatic cholangiocarcinoma or gallbladder cancer and a microscopically positive surgical resection margin (R1 resection) may be offered chemoradiation therapy. A shared decision-making approach is recommended, considering the risk of harm and potential for benefit associated with radiation therapy for patients with extrahepatic cholangiocarcinoma or gallbladder cancer.
Note6 month embargo; published online March 11, 2019
VersionFinal published version