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dc.contributor.authorHockenberry, Marilyn J
dc.contributor.authorPan, Wei
dc.contributor.authorScheurer, Michael E
dc.contributor.authorHooke, Mary C
dc.contributor.authorTaylor, Olga
dc.contributor.authorKoerner, Kari
dc.contributor.authorMontgomery, David
dc.contributor.authorWhitman, Susan
dc.contributor.authorMitby, Pauline
dc.contributor.authorMoore, Ida
dc.date.accessioned2019-09-06T22:56:12Z
dc.date.available2019-09-06T22:56:12Z
dc.date.issued2019-10-01
dc.identifier.citationHockenberry, M. J., Pan, W., Scheurer, M. E., Hooke, M. C., Taylor, O., Koerner, K., … Moore, I. (2019). Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia. Biological Research For Nursing, 21(5), 458–465. https://doi.org/10.1177/1099800419863160en_US
dc.identifier.issn1099-8004
dc.identifier.pmid31315444
dc.identifier.doi10.1177/1099800419863160
dc.identifier.urihttp://hdl.handle.net/10150/634135
dc.description.abstractPurpose: The purpose of this study was to explore the influence of oxidative stress (F2-isoprostanes) and inflammatory (interleukin [IL]-8) biomarkers on symptom trajectories during the first 18 months of childhood leukemia treatment. Method: A repeated-measures design was used to evaluate symptoms experienced by 218 children during treatment. A symptom cluster (fatigue, pain, and nausea) was explored over four time periods: initiation of post-induction therapy, 4 and 8 months into post-induction therapy, and the beginning of maintenance therapy (12 months postinduction). F2-isoprostanes and IL-8 were evaluated in cerebrospinal fluid (CSF) samples collected at baseline (diagnosis) and then at the four time periods. The longitudinal relationships of these biomarkers with the symptom cluster were examined using the longitudinal parallel process. Results: Pain and fatigue levels were highest during the post-induction phases of treatment and decreased slightly during maintenance therapy, while nausea scores were relatively stable. Even in the later phases of treatment, children continued to experience symptoms. CSF levels of the biomarkers increased during the post-induction phases of treatment. Early increases in the biomarkers were associated with more severe symptoms during the same period; patients who had increased biomarkers over time also experienced more severe symptoms over time. Conclusions: Findings reveal that children experienced symptoms throughout the course of leukemia treatment and support hypothesized longitudinal relationships of oxidative stress and inflammatory biomarkers with symptom severity. Activation of the biomarker pathways during treatment may explain underlying mechanisms of symptom experiences and identify which children are at risk for severe symptoms.en_US
dc.description.sponsorshipNational Institutes of Health [R01CA1693398]en_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.rights© The Author(s) 2019en_US
dc.subjectchildhood leukemiaen_US
dc.subjectinflammatory biomarkeren_US
dc.subjectlongitudinal parallel processen_US
dc.subjectoxidative stress biomarkeren_US
dc.subjectsymptom trajectoryen_US
dc.titleInfluence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemiaen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Coll Nursingen_US
dc.identifier.journalBIOLOGICAL RESEARCH FOR NURSINGen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleBiological research for nursing
refterms.dateFOA2019-09-06T22:56:13Z


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