Relationships between expression of BCS1L, mitochondrial bioenergetics, and fatigue among patients with prostate cancer
Veigl, Martina L
AffiliationUniv Arizona, Dept Psychol
MetadataShow full item record
PublisherDOVE MEDICAL PRESS LTD
CitationHsiao, C. P., Chen, M. K., Veigl, M. L., Ellis, R., Cooney, M., Daly, B., & Hoppel, C. (2019). Relationships between expression of BCS1L, mitochondrial bioenergetics, and fatigue among patients with prostate cancer. Cancer Management and Research, 11, 6703.
JournalCANCER MANAGEMENT AND RESEARCH
RightsCopyright © 2019 Hsiao et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractIntroduction: Cancer-related fatigue (CRF) is the most debilitating symptom with the greatest adverse side effect on quality of life. The etiology of this symptom is still not understood. The purpose of this study was to examine the relationship between mitochondrial gene expression, mitochondrial oxidative phosphorylation, electron transport chain complex activity, and fatigue in prostate cancer patients undergoing radiotherapy (XRT), compared to patients on active surveillance (AS). Methods: The study used a matched case-control and repeated-measures research design. Fatigue was measured using the revised Piper Fatigue Scale from 52 patients with prostate cancer. Mitochondrial oxidative phosphorylation, electron-transport chain enzymatic activity, and BCS1L gene expression were determined using patients' peripheral mononuclear cells. Data were collected at three time points and analyzed using repeated measures ANOVA. Results: The fatigue score was significantly different over time between patients undergoing XRT and AS (P<0.05). Patients undergoing XRT experienced significantly increased fatigue at day 21 and day 42 of XRT (P<0.01). Downregulated mitochondrial gene (BC1, ubiquinol-cytochrome c reductase, synthesis-like, BCS1L, P<0.05) expression, decreased OXPHOS-complex III oxidation (P<0.05), and reduced activity of complex III were observed over time in patients with XRT. Moreover, increased fatigue was significantly associated with downregulated BCS1L and decreased complex III oxidation in patients undergoing XRT. Conclusion: Our results suggest that BCS1L and complex III in mitochondrial mononuclear cells are potential biomarkers and feasible therapeutic targets for acute XRT-induced fatigue in this clinical population.
NoteOpen access journal
VersionFinal published version
SponsorsNational Institute of Nursing Research, National Institutes of Health [K01 NR015246]; Oncology Nursing Society Foundation, Pittsburg, PA [RES125833]; Clinical and Translational Science Collaborative Core Utilization Pilot Grant; Center for Mitochondrial Disease, Case Western Reserve University
- Integrated mitochondrial function and cancer-related fatigue in men with prostate cancer undergoing radiation therapy.
- Authors: Hsiao CP, Chen MK, Daly B, Hoppel C
- Issue date: 2018
- Differential expression of genes related to mitochondrial biogenesis and bioenergetics in fatigued prostate cancer men receiving external beam radiation therapy.
- Authors: Hsiao CP, Wang D, Kaushal A, Chen MK, Saligan L
- Issue date: 2014 Dec
- A novel mutation in BCS1L associated with deafness, tubulopathy, growth retardation and microcephaly.
- Authors: Jackson CB, Bauer MF, Schaller A, Kotzaeridou U, Ferrarini A, Hahn D, Chehade H, Barbey F, Tran C, Gallati S, Haeberli A, Eggimann S, Bonafé L, Nuoffer JM
- Issue date: 2016 Apr
- Missense mutations in the BCS1L gene as a cause of the Björnstad syndrome.
- Authors: Hinson JT, Fantin VR, Schönberger J, Breivik N, Siem G, McDonough B, Sharma P, Keogh I, Godinho R, Santos F, Esparza A, Nicolau Y, Selvaag E, Cohen BH, Hoppel CL, Tranebjaerg L, Eavey RD, Seidman JG, Seidman CE
- Issue date: 2007 Feb 22
- Impaired complex III assembly associated with BCS1L gene mutations in isolated mitochondrial encephalopathy.
- Authors: Fernandez-Vizarra E, Bugiani M, Goffrini P, Carrara F, Farina L, Procopio E, Donati A, Uziel G, Ferrero I, Zeviani M
- Issue date: 2007 May 15