Screening older adults for amnestic mild cognitive impairment and early-stage Alzheimer's disease using upper-extremity dual-tasking
Connor, Kathy O'
AffiliationUniv Arizona, Dept Biomed Engn
Univ Arizona, Coll Med, Dept Med, ACOA
Univ Arizona, Dept Med, Div Geriatr Gen Internal Med & Palliat Med
Univ Arizona, Banner Alzheimers Inst
MetadataShow full item record
PublisherNATURE PUBLISHING GROUP
CitationToosizadeh, N., Ehsani, H., Wendel, C., Zamrini, E., O’Connor, K., & Mohler, J. (2019). Screening older adults for amnestic mild cognitive impairment and early-stage Alzheimer’s disease using upper-extremity dual-tasking. Scientific reports, 9(1), 10911.
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AbstractThe purpose of the current study was to develop an objective tool based on dual-task performance for screening early-stage Alzheimer's disease (AD) and mild cognitive impairment (MCI of the Alzheimer's type). Dual-task involved a simultaneous execution of a sensor-based upper-extremity function (UEF) motor task (normal or rapid speed) and a cognitive task of counting numbers backward (by ones or threes). Motor function speed and variability were recorded and compared between cognitive groups using ANOVAs, adjusted for age, gender, and body mass index. Cognitive indexes were developed using multivariable ordinal logistic models to predict the cognitive status using UEF parameters. Ninety-one participants were recruited; 35 cognitive normal (CN, age = 83.8 +/- 6.9), 34 MCI (age = 83.9 +/- 6.6), and 22 AD (age = 84.1 +/- 6.1). Flexion number and sensor-based motion variability parameters, within the normal pace elbow flexion, showed significant between-group differences (maximum effect size of 1.10 for CN versus MCI and 1.39 for CN versus AD, p < 0.0001). Using these parameters, the cognitive status (both MCI and AD) was predicted with a receiver operating characteristic area under curve of 0.83 (sensitivity = 0.82 and specificity = 0.72). Findings suggest that measures of motor function speed and accuracy within a more practical upper-extremity test (instead of walking) may provide enough complexity for cognitive impairment assessment.
NoteOpen access journal
VersionFinal published version
SponsorsNational Institute of Aging (NIA) [1 R21 AG055852-01]
- The association between cognition and dual-tasking among older adults: the effect of motor function type and cognition task difficulty.
- Authors: Ehsani H, Mohler MJ, O'Connor K, Zamrini E, Tirambulo C, Toosizadeh N
- Issue date: 2019
- Upper-Extremity Dual-Task Function: An Innovative Method to Assess Cognitive Impairment in Older Adults.
- Authors: Toosizadeh N, Najafi B, Reiman EM, Mager RM, Veldhuizen JK, O'Connor K, Zamrini E, Mohler J
- Issue date: 2016
- Frailty assessment in older adults using upper-extremity function: index development.
- Authors: Toosizadeh N, Wendel C, Hsu CH, Zamrini E, Mohler J
- Issue date: 2017 Jun 2
- The motor signature of mild cognitive impairment: results from the gait and brain study.
- Authors: Montero-Odasso M, Oteng-Amoako A, Speechley M, Gopaul K, Beauchet O, Annweiler C, Muir-Hunter SW
- Issue date: 2014 Nov