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dc.contributor.authorAbderezaei, Javid
dc.contributor.authorZhao, Wei
dc.contributor.authorGrijalva, Carissa L.
dc.contributor.authorFabris, Gloria
dc.contributor.authorJi, Songbai
dc.contributor.authorLaksari, Kaveh
dc.contributor.authorKurt, Mehmet
dc.date.accessioned2019-09-11T00:11:17Z
dc.date.available2019-09-11T00:11:17Z
dc.date.issued2019-07-30
dc.identifier.citationAbderezaei, J., Zhao, W., Grijalva, C. L., Fabris, G., Ji, S., Laksari, K., & Kurt, M. (2019). Nonlinear Dynamical Behavior of the Deep White Matter during Head Impact. Physical Review Applied, 12(1), 014058.en_US
dc.identifier.issn2331-7019
dc.identifier.doi10.1103/physrevapplied.12.014058
dc.identifier.urihttp://hdl.handle.net/10150/634148
dc.description.abstractTraumatic brain injury (TBI) is a major public health concern, affecting as many as 3 million people each year in the U.S. Despite substantial research efforts in recent years, our physical understanding of the cause of injury remains rather limited. In this paper, we characterize the nonlinear dynamical behavior of the brain-skull system through modal analysis and advanced finite-element (FE) simulations. We observe nonlinear behavior in the deep-white-matter (WM) structures near the dural folds, with an energy redistribution of around 30% between the dominant modes. We find evidence of shear-wave redirection near the falx and the tentorium (approximately 15 degrees in the axial and 8 degrees in the coronal plane) as a result of geometric nonlinearities. The shift in the falx mode shape, which is perpendicular to the deformation of the brain, causes geometrical nonlinear effects at the falx-brain tissue boundary. This is accompanied by a lateral sliding of the tentorium below the brain tissue, which induces higher local strains at its interface with deep regions of the brain. We observe that deep regions of the brain with high principal strains coincide with the identified nonlinear regions. The onset of nonlinear behavior in brain tissue is closely associated with the previously reported concussion thresholds, suggesting a possible link between the damage mechanism and the underlying nonlinear brain biomechanics.en_US
dc.description.sponsorshipNSF [CMMI-1826270, CMMI-1728186]en_US
dc.language.isoenen_US
dc.publisherAMER PHYSICAL SOCen_US
dc.rightsCopyright © 2019 American Physical Societyen_US
dc.titleNonlinear Dynamical Behavior of the Deep White Matter during Head Impacten_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Biomed Engnen_US
dc.identifier.journalPHYSICAL REVIEW APPLIEDen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.volume12
dc.source.issue1
refterms.dateFOA2019-09-11T00:11:17Z


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