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    Understanding the Role of Polarity Regulators in Irradiated Salivary Glands Following Injury and During Regeneration

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    Author
    Wong, Wen Yu
    Issue Date
    2019
    Advisor
    Limesand, Kirsten
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Approximately 600,000 patients are diagnosed with head and neck cancer (HNC) worldwide with a 40-50% mortality rate each year. Malfunctioning salivary glands and consequential xerostomia is a common and chronic complication for patients treated with radiotherapy for HNC. While significant improvements have been achieved in the prevention and treatment of radiation-induced hyposalivation, many patients still suffer from xerostomia and other oral complications. This implies that the above-described strategies are not sufficient in restoring salivary function and secretion. Though there are efforts directed toward gene therapy, artificial salivary glands, and stem cell transplantation, these techniques are not fully standardized, nor clinically applicable yet. Considerable research efforts have focused on the role of radiation damage on the stem/progenitor cells (SPCs). Just as important, restoration of the salivary glands requires an understanding of the spatial and temporal interactions of its environment since it provides paracrine and mechanical signals to maintain the SPCs. Polarity, the intrinsic asymmetry of cellular components, plays a role in the reestablishment of the epithelization process that is necessary for directional salivary secretion. While polarity has been shown to be important in salivary development, homeostasis, and maintenance, the effects of radiation on polarity in the total parotid tissue remain largely unknown. The question of what polarity regulators are damaged, how they are damaged, and if they respond during tissue regeneration is still elusive. We propose that by understanding the role of polarity regulators following injury and during tissue regeneration, we would be able to elucidate some mechanistic insights that govern radiation-induced salivary dysfunction.
    Type
    text
    Electronic Dissertation
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Graduate College
    Cancer Biology
    Degree Grantor
    University of Arizona
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