Reservoir computing model of prefrontal cortex creates novel combinations of previous navigation sequences from hippocampal place-cell replay with spatial reward propagation
Llofriu Alonso, Martin
Scleidorovich Chiodi, Pablo
Dominey, Peter Ford
AffiliationUniv Arizona, Dept Psychol
MetadataShow full item record
PublisherPUBLIC LIBRARY SCIENCE
CitationCazin N, Llofriu Alonso M, Scleidorovich Chiodi P, Pelc T, Harland B, Weitzenfeld A, et al. (2019) Reservoir computing model of prefrontal cortex creates novel combinations of previous navigation sequences from hippocampal place-cell replay with spatial reward propagation. PLoS Comput Biol 15(7): e1006624. https://doi.org/10.1371/journal.pcbi.1006624
JournalPLOS COMPUTATIONAL BIOLOGY
RightsCopyright © 2019 Cazin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractAs rats learn to search for multiple sources of food or water in a complex environment, they generate increasingly efficient trajectories between reward sites. Such spatial navigation capacity involves the replay of hippocampal place-cells during awake states, generating small sequences of spatially related place-cell activity that we call "snippets". These snippets occur primarily during sharp-wave-ripples (SWRs). Here we focus on the role of such replay events, as the animal is learning a traveling salesperson task (TSP) across multiple trials. We hypothesize that snippet replay generates synthetic data that can substantially expand and restructure the experience available and make learning more optimal. We developed a model of snippet generation that is modulated by reward, propagated in the forward and reverse directions. This implements a form of spatial credit assignment for reinforcement learning. We use a biologically motivated computational framework known as 'reservoir computing' to model prefrontal cortex (PFC) in sequence learning, in which large pools of prewired neural elements process information dynamically through reverberations. This PFC model consolidates snippets into larger spatial sequences that may be later recalled by subsets of the original sequences. Our simulation experiments provide neurophysiological explanations for two pertinent observations related to navigation. Reward modulation allows the system to reject non-optimal segments of experienced trajectories, and reverse replay allows the system to "learn" trajectories that it has not physically experienced, both of which significantly contribute to the TSP behavior.
NoteOpen access journal
VersionFinal published version
SponsorsCRCNS NFS-ANR