Online yoga in myeloproliferative neoplasm patients: results of a randomized pilot trial to inform future research
MetadataShow full item record
CitationHuberty, J., Eckert, R., Dueck, A., Kosiorek, H., Larkey, L., Gowin, K., & Mesa, R. (2019). Online yoga in myeloproliferative neoplasm patients: results of a randomized pilot trial to inform future research. BMC complementary and alternative medicine, 19(1), 121.
RightsCopyright © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractBackground Myelo proliferative neoplasm (MPN) patients suffer from significant symptoms, inflammation and reduced quality of life. Yoga improves these outcomes in other cancers, but this hasn't been demonstrated in MPNs. The purpose of this study was to: (1) explore the limited efficacy (does the program show promise of success) of a 12-week online yoga intervention among MPN patients on symptom burden and quality of life and (2) determine feasibility (practicality: to what extent a measure can be carried out) of remotely collecting inflammatory biomarkers. Methods Patients were recruited nationally and randomized to online yoga (60min/week of yoga) or wait-list control (asked to maintain normal activity). Weekly yoga minutes were collected with Clicky (online web analytics tool) and self-report. Those in online yoga completed a blood draw at baseline and week 12 to assess inflammation (interleukin-6, tumor necrosis factor-alpha [TNF-]). All participants completed questionnaires assessing depression, anxiety, fatigue, pain, sleep disturbance, sexual function, total symptom burden, global health, and quality of life at baseline, week seven, 12, and 16. Change from baseline at each time point was computed by group and effect sizes were calculated. Pre-post intervention change in inflammation for the yoga group was compared by t-test. Results Sixty-two MPN patients enrolled and 48 completed the intervention (online yoga=27; control group=21). Yoga participation averaged 40.8min/week via Clicky and 56.1min/week via self-report. Small/moderate effect sizes were generated from the yoga intervention for sleep disturbance (d=-0.26 to -0.61), pain intensity (d=-0.34 to -0.51), anxiety (d=-0.27 to -0.37), and depression (d=-0.53 to -0.78). A total of 92.6 and 70.4% of online yoga participants completed the blood draw at baseline and week 12, respectively, and there was a decrease in TNF- from baseline to week 12 (-1.31.5pg/ml). Conclusions Online yoga demonstrated small effects on sleep, pain, and anxiety as well as a moderate effect on depression. Remote blood draw procedures are feasible and the effect size of the intervention on TNF- was large. Future fully powered randomized controlled trials are needed to test for efficacy. Trial registration This trial was retrospectively registered with clinicaltrials.gov (ID: NCT03503838) on 4/19/2018.
NoteOpen access journal
VersionFinal published version
Sponsorsphilanthropically derived MPN research funds
- Perceptions of Myeloproliferative Neoplasm Patients Participating in an Online Yoga Intervention: A Qualitative Study.
- Authors: Huberty J, Eckert R, Larkey L, Gowin K, Mitchell J, Mesa R
- Issue date: 2018 Dec
- Smartphone-Based Meditation for Myeloproliferative Neoplasm Patients: Feasibility Study to Inform Future Trials.
- Authors: Huberty J, Eckert R, Larkey L, Kurka J, Rodríguez De Jesús SA, Yoo W, Mesa R
- Issue date: 2019 Apr 29
- Acceptability and feasibility of a 12-week yoga vs. educational film program for the management of restless legs syndrome (RLS): study protocol for a randomized controlled trial.
- Authors: Selfe TK, Wen S, Sherman K, Klatt M, Innes KE
- Issue date: 2019 Feb 15
- Yoga improves occupational performance, depression, and daily activities for people with chronic pain.
- Authors: Schmid AA, Van Puymbroeck M, Fruhauf CA, Bair MJ, Portz JD
- Issue date: 2019
- Online yoga to reduce post traumatic stress in women who have experienced stillbirth: a randomized control feasibility trial.
- Authors: Huberty J, Sullivan M, Green J, Kurka J, Leiferman J, Gold K, Cacciatore J
- Issue date: 2020 Jun 5