APOL1 renal risk alleles in patients on chronic hemodialysis in Northwest of Iran
AuthorVahed, Sepideh Zuntmi
Attari, Vahideh Ebrahimzadeh
Shojas, Mohammadali Mohajel
AffiliationUniv Arizona, Div Nephrol
KeywordsChronic kidney disease
End-stage renal disease
Chronic renal failure
MetadataShow full item record
PublisherNIKAN RESEARCH INST
CitationZununi Vahed S, Rikhtegar E, Ebrahimzadeh V, Haghi M, Tolouian R, Mohajel Shoja M, et al. APOL1 renal risk alleles in patients on chronic hemodialysis in Northwest of Iran. J Renal Inj Prev. 2019; 8(3): 199-203. DOI: 10.15171/jrip.2019.37.
RightsCopyright © 2019 The Author(s); Published by Nickan Research Institute. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.or/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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AbstractIntroduction: Apolipoprotein L1 (APOL1) gene's risk variants located on chromosome 22 are newly discovered factors for the development of chronic renal failure among African-American. These risk alleles were developed on the African continent as an evolutionary defense against sleep sickness due to Trypanosoma brucei rhodesiense and then spread with human migrations. Objectives: In the present study, we sought to examine these risk variants in a group of hemodialysis patients of Northwest of Iran. Patients and Methods: Two hundred patients receiving hemodialysis in different centers of the city (Tabriz in Northwest of Iran) were allocated randomly from a total number of 825 patients. The assessment of APOL1 polymorphisms (rs73885319, rs60910145, and rs71785313) was conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Patients' demographic data, history, and their biochemical parameters were recorded based on their last measurement. Results: No proposed renal risk variants of APOL1 gene in our hemodialysis population were found. All the participants had a wild genotype. Conclusion: The results of our study match with reports from Europe and Asia. In the paleoanthropological point of view, our results do not support African human migration hypothesis.
NoteOpen access journal
VersionFinal published version
SponsorsKidney Research Center of Tabriz University of Medical Sciences, Tabriz, Iran [5/D/489418]