Evolution of Asian Corn Borer Resistance to Bt Toxins Used Singly or in Pairs
Gatehouse, Angharad M R
Tabashnik, Bruce E
AffiliationUniv Arizona, Dept Entomol
MetadataShow full item record
CitationWang, Y.; Quan, Y.; Yang, J.; Shu, C.; Wang, Z.; Zhang, J.; Gatehouse, A.M.R.; Tabashnik, B.E.; He, K. Evolution of Asian Corn Borer Resistance to Bt Toxins Used Singly or in Pairs. Toxins 2019, 11, 461.
RightsCopyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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AbstractTransgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt) have revolutionized pest control, but the benefits of this approach have been reduced by the evolution of resistance in pests. The widely adopted 'pyramid strategy' for delaying resistance entails transgenic crops producing two or more distinct toxins that kill the same pest. The limited experimental evidence supporting this strategy comes primarily from a model system under ideal conditions. Here we tested the pyramid strategy under nearly worst-case conditions, including some cross-resistance between the toxins in the pyramid. In a laboratory selection experiment with an artificial diet, we used Bt toxins Cry1Ab, Cry1F, and Cry1Ie singly or in pairs against Ostrinia furnacalis, one of the most destructive pests of corn in Asia. Under the conditions evaluated, pairs of toxins did not consistently delay the evolution of resistance relative to single toxins.
NoteOpen access journal
VersionFinal published version
SponsorsKey Project for Breeding Genetically Modified Organisms Grant from the USDA National Institute of Food and Agriculture [2016ZX08003-001]; Agriculture and Food Research Initiative Program from the USDA National Institute of Food and Agriculture [2018-67013-27821]