Real supermodels wear wool: summarizing the impact of the pregnant sheep as an animal model for adaptive fetal programming
AffiliationUniv Arizona, Sch Anim & Comparat Biomed Sci
intrauterine growth restriction
MetadataShow full item record
PublisherOXFORD UNIV PRESS INC
CitationKristin A Beede, Sean W Limesand, Jessica L Petersen, Dustin T Yates, Real supermodels wear wool: summarizing the impact of the pregnant sheep as an animal model for adaptive fetal programming, Animal Frontiers, Volume 9, Issue 3, July 2019, Pages 34–43, https://doi.org/10.1093/af/vfz018
RightsCopyright © Beede, Limesand, Petersen, and Yates. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. doi: 10.1093/af/vfz018
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractImplications: Intrauterine growth restriction (IUGR) continues to be a global epidemic that is associated with high early-life mortality rates and greater risk for developing metabolic disorders that lower length and quality of life in affected individuals. Fetal programming of muscle growth and metabolic function associated with IUGR is often comparable among nonlitter bearing mammalian species, which allows much of the information learned in domestic animal models to be applicable to humans (and other animals). Recent studies in sheep models of IUGR have begun to uncover the molecular mechanisms linking adaptive fetal programming and metabolic dysfunction. Targets of adaptive fetal programming indicated by sheep studies include adrenergic and inflammatory pathways that regulate skeletal muscle growth and glucose metabolism. Adaptive changes in these pathways represent potential focus areas for prenatal interventions or postnatal treatments to improve outcomes in IUGR-born offspring.
NoteOpen access journal
VersionFinal published version
SponsorsNational Institute of General Medical Sciences [1P20GM104320]; Nebraska Agricultural Experiment Station; USDA National Institute of Food and Agriculture [1011126, 1011055, 1009410]; NIH (NIGMS) COBRE IDeA award [NIH 1P20GM104320]