SFRP4 expression correlates with epithelial mesenchymal transition-linked genes and poor overall survival in colon cancer patients
AffiliationUniv Arizona, Dept Surg
MetadataShow full item record
PublisherBAISHIDENG PUBLISHING GROUP INC
CitationNfonsam, Landry & Jandova, Jana & Jecius, Hunter & Omesiete, Pamela & Nfonsam, Valentine. (2019). SFRP4 expression correlates with epithelial mesenchymal transition-linked genes and poor overall survival in colon cancer patients. World Journal of Gastrointestinal Oncology. 11. 589-598. 10.4251/wjgo.v11.i8.589.
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AbstractColon cancer is among the most commonly diagnosed cancers in the United States with an estimated 97220 new cases expected by the end of 2018. It affects 1.2 million people around the world and is responsible for about 0.6 million deaths every year. Despite decline in overall incidence and mortality over the past 30 years, there continues to be an alarming rise in early-onset colon cancer cases (< 50 years). Patients are often diagnosed at late stages of the disease and tend to have poor survival. We previously showed that the WNT "gatekeeper" gene, secreted frizzled-related protein 4 (SFRP4), is over-expressed in early-onset colon cancer. SFRP4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition (EMT).
NoteOpen access journal
VersionFinal published version
SponsorsSAGES research grant