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    PD-1 Inhibition Achieves a Complete Metabolic Response in a Patient with Malignant Peripheral Nerve Sheath Tumor

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    Thumbnail
    Name:
    Revised CIR-19-0072R-FINAL.pdf
    Size:
    1.144Mb
    Format:
    PDF
    Description:
    Final Accepted Manuscript
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    Author
    Davis, Lisa E
    Nicholls, Lauren A
    Babiker, Hani M
    Liau, Joy
    Mahadevan, Daruka
    Affiliation
    Univ Arizona, Coll Pharm, Dept Pharm Practice & Sci
    Univ Arizona, Ctr Canc
    Univ Arizona, Coll Med, Dept Med
    Univ Arizona, Coll Med, Dept Med Imaging
    Issue Date
    2019-09-01
    
    Metadata
    Show full item record
    Publisher
    AMER ASSOC CANCER RESEARCH
    Citation
    Davis, L. E., Nicholls, L. A., Babiker, H. M., Liau, J., & Mahadevan, D. (2019). PD-1 Inhibition Achieves a Complete Metabolic Response in a Patient with Malignant Peripheral Nerve Sheath Tumor. Cancer immunology research, 7(9), 1396-1400.
    Journal
    CANCER IMMUNOLOGY RESEARCH
    Rights
    Copyright © 2019 American Association for Cancer Research.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    High-grade malignant peripheral nerve sheath tumors (MPNST) have a poor prognosis with limited responsiveness to systemic therapy. We document a case of a complete metabolic response to pembrolizumab monotherapy in metastatic disease. Tumor molecular profiling identified programmed-death ligand-1 (PD-L1) positivity. This characteristic provided a rationale for immune-checkpoint therapy. Treatment with pembrolizumab resulted in a complete metabolic response after four cycles of therapy. Patients with PD-L1-positive, metastatic MPNST may be candidates for immune-checkpoint therapy, which may produce a durable completere mission. Future study of anti-PD-1/PD-L1 therapy is warranted.
    Note
    12 month embargo; published online: 1 September 2019
    ISSN
    2326-6066
    PubMed ID
    31383651
    DOI
    10.1158/2326-6066.CIR-19-0072
    Version
    Final accepted manuscript
    Sponsors
    CCSG P30 supplement from the NCI
    ae974a485f413a2113503eed53cd6c53
    10.1158/2326-6066.CIR-19-0072
    Scopus Count
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    UA Faculty Publications

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