New Intrusion Analyses on the CVLT-3: Utility in Distinguishing the Memory Disorders of Alzheimer's Huntington's Disease
AuthorGraves, Lisa V
Holden, Heather M
Van Etten, Emily J
Bondi, Mark W
Salmon, David P
Gilbert, Paul E
Delis, Dean C
AffiliationUniv Arizona, Dept Psychol
Memory and learning tests
MetadataShow full item record
PublisherCAMBRIDGE UNIV PRESS
CitationGraves, L., Holden, H., Van Etten, E., Delano-Wood, L., Bondi, M., Salmon, D., . . . Delis, D. (2019). New Intrusion Analyses on the CVLT-3: Utility in Distinguishing the Memory Disorders of Alzheimer’s versus Huntington’s Disease. Journal of the International Neuropsychological Society, 25(8), 878-883. doi:10.1017/S1355617719000407
RightsCopyright © INS. Published by Cambridge University Press, 2019.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractObjectives: Research has shown that analyzing intrusion errors generated on verbal learning and memory measures is helpful for distinguishing between the memory disorders associated with Alzheimer's disease (AD) and other neurological disorders, including Huntington's disease (HD). Moreover, preliminary evidence suggests that certain clinical populations may be prone to exhibit different types of intrusion errors. Methods: We examined the prevalence of two new California Verbal Learning Test-3 (CVLT-3) intrusion subtypes - across-trial novel intrusions and across/within trial repeated intrusions - in individuals with AD or HD. We hypothesized that the encoding/storage impairment associated with medial-temporal involvement in AD would result in a greater number of novel intrusions on the delayed recall trials of the CVLT-3, whereas the executive dysfunction associated with subcortical-frontal involvement in HD would result in a greater number of repeated intrusions across trials. Results: The AD group generated significantly more across-trial novel intrusions than across/within trial repeated intrusions on the delayed cued-recall trials, whereas the HD group showed the opposite pattern on the delayed free-recall trials. Conclusions: These new intrusion subtypes, combined with traditional memory analyses (e.g., recall versus recognition performance), promise to enhance our ability to distinguish between the memory disorders associated with primarily medial-temporal versus subcortical-frontal involvement.
VersionFinal published version
SponsorsNational Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 AG034202, P30 AG059299, K24 AG026431, R01 AG049810, P50 AG005131]; Huntington's Disease Society of America Center of Excellence
- New Yes/No Recognition Memory Analysis on the California Verbal Learning Test-3: Clinical Utility in Alzheimer's and Huntington's Disease.
- Authors: Graves LV, Holden HM, Van Etten EJ, Delano-Wood L, Bondi MW, Salmon DP, Corey-Bloom J, Delis DC, Gilbert PE
- Issue date: 2018 Sep
- Verbal memory performance of patients with human immunodeficiency virus infection: evidence of subcortical dysfunction. The HNRC Group.
- Authors: Peavy G, Jacobs D, Salmon DP, Butters N, Delis DC, Taylor M, Massman P, Stout JC, Heindel WC, Kirson D
- Issue date: 1994 Aug
- Verbal intrusions precede memory decline in adults with Down syndrome.
- Authors: Kittler P, Krinsky-McHale SJ, Devenny DA
- Issue date: 2006 Jan
- Recall and Recognition Discriminability in Parkinson's Disease and Huntington's Disease.
- Authors: Van Etten EJ, Graves LV, Taylor B, Holden HM, Lopez FV, Williams ME, Pirogovsky-Turk E, Corey-Bloom J, Filoteo JV, Delis DC, Gilbert PE
- Issue date: 2019
- Error analysis of the nine-word California Verbal Learning Test (CVLT-9) among older adults with and without dementia.
- Authors: Davis KL, Price CC, Kaplan E, Libon DJ
- Issue date: 2002 Feb