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dc.contributor.authorGraves, Lisa V
dc.contributor.authorHolden, Heather M
dc.contributor.authorVan Etten, Emily J
dc.contributor.authorDelano-Wood, Lisa
dc.contributor.authorBondi, Mark W
dc.contributor.authorSalmon, David P
dc.contributor.authorCorey-Bloom, Jody
dc.contributor.authorGilbert, Paul E
dc.contributor.authorDelis, Dean C
dc.date.accessioned2019-10-09T21:33:04Z
dc.date.available2019-10-09T21:33:04Z
dc.date.issued2019-05-07
dc.identifier.citationGraves, L., Holden, H., Van Etten, E., Delano-Wood, L., Bondi, M., Salmon, D., . . . Delis, D. (2019). New Intrusion Analyses on the CVLT-3: Utility in Distinguishing the Memory Disorders of Alzheimer’s versus Huntington’s Disease. Journal of the International Neuropsychological Society, 25(8), 878-883. doi:10.1017/S1355617719000407en_US
dc.identifier.issn1355-6177
dc.identifier.pmid31060638
dc.identifier.doi10.1017/S1355617719000407
dc.identifier.urihttp://hdl.handle.net/10150/634727
dc.description.abstractObjectives: Research has shown that analyzing intrusion errors generated on verbal learning and memory measures is helpful for distinguishing between the memory disorders associated with Alzheimer's disease (AD) and other neurological disorders, including Huntington's disease (HD). Moreover, preliminary evidence suggests that certain clinical populations may be prone to exhibit different types of intrusion errors. Methods: We examined the prevalence of two new California Verbal Learning Test-3 (CVLT-3) intrusion subtypes - across-trial novel intrusions and across/within trial repeated intrusions - in individuals with AD or HD. We hypothesized that the encoding/storage impairment associated with medial-temporal involvement in AD would result in a greater number of novel intrusions on the delayed recall trials of the CVLT-3, whereas the executive dysfunction associated with subcortical-frontal involvement in HD would result in a greater number of repeated intrusions across trials. Results: The AD group generated significantly more across-trial novel intrusions than across/within trial repeated intrusions on the delayed cued-recall trials, whereas the HD group showed the opposite pattern on the delayed free-recall trials. Conclusions: These new intrusion subtypes, combined with traditional memory analyses (e.g., recall versus recognition performance), promise to enhance our ability to distinguish between the memory disorders associated with primarily medial-temporal versus subcortical-frontal involvement.en_US
dc.description.sponsorshipNational Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 AG034202, P30 AG059299, K24 AG026431, R01 AG049810, P50 AG005131]; Huntington's Disease Society of America Center of Excellenceen_US
dc.language.isoenen_US
dc.publisherCAMBRIDGE UNIV PRESSen_US
dc.rightsCopyright © INS. Published by Cambridge University Press, 2019.en_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectHuntington diseaseen_US
dc.subjectMemoryen_US
dc.subjectMemory and learning testsen_US
dc.subjectMemory disordersen_US
dc.subjectNeuropsychological testsen_US
dc.subjectVerbal learningen_US
dc.titleNew Intrusion Analyses on the CVLT-3: Utility in Distinguishing the Memory Disorders of Alzheimer's Huntington's Diseaseen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Psycholen_US
dc.identifier.journalJOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETYen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleJournal of the International Neuropsychological Society : JINS
refterms.dateFOA2019-10-09T21:33:05Z


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