Show simple item record

dc.contributor.authorBatai, Ken
dc.contributor.authorHarb-De la Rosa, Alfredo
dc.contributor.authorZeng, Jiping
dc.contributor.authorChipollini, Juan J
dc.contributor.authorGachupin, Francine C
dc.contributor.authorLee, Benjamin R
dc.date.accessioned2019-10-09T22:43:11Z
dc.date.available2019-10-09T22:43:11Z
dc.date.issued2019-09-11
dc.identifier.citationBatai K, Harb‐De la Rosa A, Zeng J, Chipollini JJ, Gachupin FC, Lee BR. Racial/ethnic disparities in renal cell carcinoma: Increased risk of early‐onset and variation in histologic subtypes. Cancer Med. 2019; 00: 1–9. https ://doi.org/10.1002/cam4.2552en_US
dc.identifier.issn2045-7634
dc.identifier.pmid31509346
dc.identifier.doi10.1002/cam4.2552
dc.identifier.urihttp://hdl.handle.net/10150/634737
dc.description.abstractBackground Racial/ethnic minority groups have a higher burden of renal cell carcinoma (RCC), but RCC among Hispanic Americans (HAs) and American Indians and Alaska Natives (AIs/ANs) are clinically not well characterized. We explored variations in age at diagnosis and frequencies of RCC histologic subtypes across racial/ethnic groups and Hispanic subgroups using National Cancer Database (NCDB) and Arizona Cancer Registry Data. Methods Adult RCC cases with known race/ethnicity were included. Logistic regression analysis was performed to estimate odds and 95% confidence interval (CI) of early-onset (age at diagnosis <50 years) and diagnosis with clear cell RCC (ccRCC) or papillary RCC. Results A total of 405 073 RCC cases from NCDB and 9751 cases from ACR were identified and included. In both datasets, patients from racial/ethnic minority groups had a younger age at diagnosis than non-Hispanic White (NHW) patients. In the NCDB, AIs/ANs had twofold increased odds (OR, 2.21; 95% CI, 1.88-2.59) of early-onset RCC compared with NHWs. HAs also had twofold increased odds of early-onset RCC (OR, 2.14; 95% CI, 1.79-2.55) in the ACR. In NCDB, ccRCC was more prevalent in AIs (86.3%) and Mexican Americans (83.5%) than NHWs (72.5%). AIs/ANs had twofold increased odds of diagnosis with ccRCC (OR, 2.18; 95% CI, 1.85-2.58) in the NCDB, but the association was stronger in the ACR (OR, 2.83; 95% CI, 2.08-3.85). Similarly, Mexican Americans had significantly increased odds of diagnosis with ccRCC (OR, 2.00; 95% CI, 1.78-2.23) in the NCDB. Conclusions This study reports younger age at diagnosis and higher frequencies of ccRCC histologic subtype in AIs/ANs and Hispanic subgroups. These variations across racial/ethnic groups and Hispanic subgroups may have potential clinical implications.en_US
dc.description.sponsorshipUrology Care Foundation; National Cancer Institute Cancer CenterUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30CA023074]; Partnership for Native American Cancer Prevention (NACP) [U54CA143924, U54CA143925]en_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.rightsCopyright © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectAmerican Indiansen_US
dc.subjectHispanic Americansen_US
dc.subjectearly onseten_US
dc.subjecthealth disparitiesen_US
dc.subjectrenal cell carcinoma subtypesen_US
dc.titleRacial/ethnic disparities in renal cell carcinoma: Increased risk of early-onset and variation in histologic subtypesen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Urolen_US
dc.contributor.departmentUniv Arizona, Dept Family & Community Meden_US
dc.identifier.journalCANCER MEDICINEen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleCancer medicine
refterms.dateFOA2019-10-09T22:43:11Z


Files in this item

Thumbnail
Name:
Batai_et_al-2019-Cancer_Medici ...
Size:
215.8Kb
Format:
PDF
Description:
Final Published Version

This item appears in the following Collection(s)

Show simple item record