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dc.contributor.authorLindeman, Leila R
dc.contributor.authorJones, Kyle M
dc.contributor.authorHigh, Rachel A
dc.contributor.authorHowison, Christine M
dc.contributor.authorShubitz, Lisa F
dc.contributor.authorPagel, Mark D
dc.date.accessioned2019-10-10T19:37:53Z
dc.date.available2019-10-10T19:37:53Z
dc.date.issued2019-09-10
dc.identifier.citationLindeman, L. R., Jones, K. M., High, R. A., Howison, C. M., Shubitz, L. F., & Pagel, M. D. (2019). Differentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRI. Scientific reports, 9(1), 1-8.en_US
dc.identifier.issn2045-2322
dc.identifier.pmid31506562
dc.identifier.doi10.1038/s41598-019-49514-1
dc.identifier.urihttp://hdl.handle.net/10150/634743
dc.description.abstractLung cancer diagnosis via imaging may be confounded by the presence of indolent infectious nodules in imaging studies. This issue is pervasive in the southwestern US where coccidioidomycosis (Valley Fever) is endemic. AcidoCEST MRI is a noninvasive imaging method that quantifies the extracellular pH (pHe) of tissues in vivo, allowing tumor acidosis to be used as a diagnostic biomarker. Using murine models of lung adenocarcinoma and coccidoidomycosis, we found that average lesion pHe differed significantly between tumors and granulomas. Our study shows that acidoCEST MRI is a promising tool for improving the specificity of lung cancer diagnosis.en_US
dc.description.sponsorshipNIH United States Department of Health & Human Services National Institutes of Health (NIH) - USA [R01CA167183, P30CA023074, T32CA009213]en_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.rightsCopyright © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.titleDifferentiating lung cancer and infection based on measurements of extracellular pH with acidoCEST MRIen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Med Imagingen_US
dc.contributor.departmentUniv Arizona, Valley Fever Ctr Excellenceen_US
dc.contributor.departmentUniv Arizona, Canc Biol Grad Interdisciplinary Programen_US
dc.contributor.departmentUniv Arizona, Bioengn Grad Interdisciplinary Programen_US
dc.identifier.journalSCIENTIFIC REPORTSen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleScientific reports
refterms.dateFOA2019-10-10T19:37:53Z


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