Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system

Thumbnail
Name:
1-s2.0-S2213158219302554-main.pdf
Size:
1.181Mb
Format:
PDF
Description:
Final Published Version
Download
Author
Jassar, Hassan
Nascimento, Thiago D
Kaciroti, Niko
DosSantos, Marcos F
Danciu, Theodora
Koeppe, Robert A
Smith, Yolanda R
Bigal, Marcelo E
Porreca, Frank
Casey, Kenneth L
Affiliation
Univ Arizona, Dept Pharmacol
Issue Date
2019-01-01
Keywords
Central pain
MRI
Migraine
Opioid
PET
Thermal pain threshold

Metadata
Show full item record
Publisher
ELSEVIER SCI LTD
Citation
Jassar, H., Nascimento, T. D., Kaciroti, N., DosSantos, M. F., Danciu, T., Koeppe, R. A., ... & Zubieta, J. K. (2019). Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system. NeuroImage: Clinical, 101905.
Journal
NEUROIMAGE-CLINICAL
Rights
Copyright © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
Abstract
We scanned 15 migraine patients during the spontaneous headache attack (ictal phase): 7 individuals with CM and 8 with episodic migraine (EM), as well as 7 healthy controls (HC), using positron emission tomography (PET) with the selective μ-opioid receptor (μOR) radiotracer [11C]carfentanil. Migraineurs were scanned in two paradigms, one with thermal pain threshold challenge applied to the site of the headache, and one without thermal challenge. Multivariable analysis was performed between the μ-opioid receptor availability and the clinical data.
Note
Open access journal
ISSN
2213-1582
PubMed ID
31279240
DOI
10.1016/j.nicl.2019.101905
Version
Final published version
Sponsors
National Institute of Health -National Institute of Neurological Disorders and Stroke, USA [NIH-NINDS K23 NS062946, R01 NS094413]; Dana Foundation's Brain and Immuno-Imaging Award, USA; Migraine Research Foundation Research Grant Award, USA
Collections
Copyright © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Except where otherwise noted, this item's license is described as Copyright © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).