Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system
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Author
Jassar, HassanNascimento, Thiago D
Kaciroti, Niko
DosSantos, Marcos F
Danciu, Theodora
Koeppe, Robert A
Smith, Yolanda R
Bigal, Marcelo E
Porreca, Frank
Casey, Kenneth L
Zubieta, Jon-Kar
DaSilva, Alexandre F
Affiliation
Univ Arizona, Dept PharmacolIssue Date
2019-01-01
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Jassar, H., Nascimento, T. D., Kaciroti, N., DosSantos, M. F., Danciu, T., Koeppe, R. A., ... & Zubieta, J. K. (2019). Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system. NeuroImage: Clinical, 101905.Journal
NEUROIMAGE-CLINICALRights
Copyright © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
We scanned 15 migraine patients during the spontaneous headache attack (ictal phase): 7 individuals with CM and 8 with episodic migraine (EM), as well as 7 healthy controls (HC), using positron emission tomography (PET) with the selective μ-opioid receptor (μOR) radiotracer [11C]carfentanil. Migraineurs were scanned in two paradigms, one with thermal pain threshold challenge applied to the site of the headache, and one without thermal challenge. Multivariable analysis was performed between the μ-opioid receptor availability and the clinical data.Note
Open access journalISSN
2213-1582PubMed ID
31279240Version
Final published versionSponsors
National Institute of Health -National Institute of Neurological Disorders and Stroke, USA [NIH-NINDS K23 NS062946, R01 NS094413]; Dana Foundation's Brain and Immuno-Imaging Award, USA; Migraine Research Foundation Research Grant Award, USAae974a485f413a2113503eed53cd6c53
10.1016/j.nicl.2019.101905
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Except where otherwise noted, this item's license is described as Copyright © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
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