Replacing Saturated Fat With Walnuts or Vegetable Oils Improves Central Blood Pressure and Serum Lipids in Adults at Risk for Cardiovascular Disease: A Randomized Controlled-Feeding Trial
AuthorTindall, Alyssa M
Petersen, Kristina S
Skulas-Ray, Ann C
Richter, Chesney K
Proctor, David N
Kris-Etherton, Penny M
AffiliationUniv Arizona, Dept Nutr Sci
polyunsaturated fatty acids
MetadataShow full item record
CitationTindall, A. M., Petersen, K. S., Skulas‐Ray, A. C., Richter, C. K., Proctor, D. N., & Kris‐Etherton, P. M. (2019). Replacing Saturated Fat With Walnuts or Vegetable Oils Improves Central Blood Pressure and Serum Lipids in Adults at Risk for Cardiovascular Disease: A Randomized Controlled‐Feeding Trial. Journal of the American Heart Association, 8(9).
RightsCopyright © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractBackground-Walnuts have beneficial effects on cardiovascular risk factors, but it is unclear whether these effects are attributable to the fatty acid (FA) content, including alpha-linolenic acid (ALA), and/or bioactives. Methods and Results-A randomized, controlled, 3-period, crossover, feeding trial was conducted in individuals at risk for cardiovascular disease (n=45). Following a 2-week standard Western diet run-in (12% saturated FAs [SFA], 7% polyunsaturated FAs, 12% monounsaturated FAs), participants consumed 3 isocaloric weight-maintenance diets for 6 weeks each: a walnut diet (WD; 7% SFA, 16% polyunsaturated FAs, 3% ALA, 9% monounsaturated FAs); a walnut FA-matched diet; and an oleic acid-replaced-ALA diet (7% SFA, 14% polyunsaturated FAs, 0.5% ALA, 12% monounsaturated FAs), which substituted the amount of ALA from walnuts in the WD with oleic acid. This design enabled evaluation of the effects of whole walnuts versus constituent components. The primary end point, central systolic blood pressure, was unchanged, and there were no significant changes in arterial stiffness. There was a treatment effect (P=0.04) for central diastolic blood pressure; there was a greater change following the WD versus the oleic acid-replaced-ALA diet (-1.78 +/- 1.0 versus 0.15 +/- 0.7 mm Hg, P=0.04). There were no differences between the WD and the walnut fatty acid-matched diet (-0.22 +/- 0.8 mm Hg, P=0.20) or the walnut FA-matched and oleic acid-replaced-ALA diets (P=0.74). The WD significantly lowered brachial and central mean arterial pressure. All diets lowered total cholesterol, LDL (low-density lipoprotein) cholesterol, HDL (high-density lipoprotein) cholesterol, and non-HDL cholesterol. Conclusions-Cardiovascular benefits occurred with all moderate-fat, high-unsaturated-fat diets. As part of a low-SFA diet, the greater improvement in central diastolic blood pressure following the WD versus the oleic acid-replaced-ALA diet indicates benefits of walnuts as a whole-food replacement for SFA.
NoteOpen access journal
VersionFinal published version
SponsorsCalifornia Walnut Commission; Pennsylvania State University Clinical and Translational Research Institute; Pennsylvania State University Clinical and Translational Science Award; National Institutes of Health/National Center for Advancing Translational Sciences [UL1TR000127]
- Walnuts and Vegetable Oils Containing Oleic Acid Differentially Affect the Gut Microbiota and Associations with Cardiovascular Risk Factors: Follow-up of a Randomized, Controlled, Feeding Trial in Adults at Risk for Cardiovascular Disease.
- Authors: Tindall AM, McLimans CJ, Petersen KS, Kris-Etherton PM, Lamendella R
- Issue date: 2020 Apr 1
- Replacing Saturated Fats with Unsaturated Fats from Walnuts or Vegetable Oils Lowers Atherogenic Lipoprotein Classes Without Increasing Lipoprotein(a).
- Authors: Tindall AM, Kris-Etherton PM, Petersen KS
- Issue date: 2020 Apr 1
- Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function.
- Authors: West SG, Krick AL, Klein LC, Zhao G, Wojtowicz TF, McGuiness M, Bagshaw DM, Wagner P, Ceballos RM, Holub BJ, Kris-Etherton PM
- Issue date: 2010 Dec
- Balance of unsaturated fatty acids is important to a cholesterol-lowering diet: comparison of mid-oleic sunflower oil and olive oil on cardiovascular disease risk factors.
- Authors: Binkoski AE, Kris-Etherton PM, Wilson TA, Mountain ML, Nicolosi RJ
- Issue date: 2005 Jul
- An acute intake of a walnut-enriched meal improves postprandial adiponectin response in healthy young adults.
- Authors: Lozano A, Perez-Martinez P, Marin C, Tinahones FJ, Delgado-Lista J, Cruz-Teno C, Gomez-Luna P, Rodriguez-Cantalejo F, Perez-Jimenez F, Lopez-Miranda J
- Issue date: 2013 Dec