Sudden-onset Hypoglycemia Following Fluid Replacement in a Patient with Dapagliflozin-induced Diabetic Ketoacidosis Without Prior Insulin Use: Case Report
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Univ Arizona, Coll Med Phoenix, Endocrinol Diabet & MetabIssue Date
2019-08-21Keywords
diabetic ketoacidosishypoglycemia
metformin
sodium-glucose co transporter-2 (sglt2) inhibitors
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CUREUS INCCitation
Elshimy G, Correa R (August 21, 2019) Sudden-onset Hypoglycemia Following Fluid Replacement in a Patient with Dapagliflozin-induced Diabetic Ketoacidosis Without Prior Insulin Use: Case Report. Cureus 11(8): e5448. doi:10.7759/cureus.5448Journal
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© Copyright 2019 Elshimy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Euglycemic diabetic ketoacidosis (DKA) is a known complication of sodium-glucose co-transporter 2 (SGLT-2) inhibitors that have been reported in the literature. The prevalence of this side effect is growing and the exact mechanism of action on why this happens is unknown. Hypoglycemia events are very rare in diabetic patients using SGLT-2 inhibitors and/or metformin when they have normal kidney function. We report a novel complication of hypoglycemia that occurred during the course of treatment of SGLT2 inhibitor-induced DKA in a patient with type 2 diabetes mellitus (T2DM) on the dapagliflozin-metformin combination.Note
Open access journalISSN
2168-8184PubMed ID
31489272Version
Final published versionScopus Count
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Except where otherwise noted, this item's license is described as © Copyright 2019 Elshimy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0.