Sudden-onset Hypoglycemia Following Fluid Replacement in a Patient with Dapagliflozin-induced Diabetic Ketoacidosis Without Prior Insulin Use: Case Report

Elshimy, Ghada; Correa, Ricardo

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Author

Elshimy, Ghada
Correa, Ricardo

Affiliation

Univ Arizona, Coll Med Phoenix, Endocrinol Diabet & Metab

Issue Date

2019-08-21

Citation

Elshimy G, Correa R (August 21, 2019) Sudden-onset Hypoglycemia Following Fluid Replacement in a Patient with Dapagliflozin-induced Diabetic Ketoacidosis Without Prior Insulin Use: Case Report. Cureus 11(8): e5448. doi:10.7759/cureus.5448

Journal

CUREUS

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© Copyright 2019 Elshimy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.

Abstract

Euglycemic diabetic ketoacidosis (DKA) is a known complication of sodium-glucose co-transporter 2 (SGLT-2) inhibitors that have been reported in the literature. The prevalence of this side effect is growing and the exact mechanism of action on why this happens is unknown. Hypoglycemia events are very rare in diabetic patients using SGLT-2 inhibitors and/or metformin when they have normal kidney function. We report a novel complication of hypoglycemia that occurred during the course of treatment of SGLT2 inhibitor-induced DKA in a patient with type 2 diabetes mellitus (T2DM) on the dapagliflozin-metformin combination.

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Open access journal

ISSN

2168-8184

PubMed ID

31489272

DOI

10.7759/cureus.5448

Version

Final published version

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UA Faculty Publications

© Copyright 2019 Elshimy et al. This is an open access article distributed under the terms of the Creative Commons Attribution
License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Except where otherwise noted, this item's license is described as © Copyright 2019 Elshimy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.