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dc.contributor.authorChinyere, Ikeotunye Royal
dc.contributor.authorHutchinson, Mathew
dc.contributor.authorMoukabary, Talal
dc.contributor.authorLancaster, Jordan
dc.contributor.authorGoldman, Steven
dc.contributor.authorJuneman, Elizabeth
dc.date.accessioned2019-10-24T00:41:43Z
dc.date.available2019-10-24T00:41:43Z
dc.date.issued2019-10-01
dc.identifier.citationChinyere, I. R., Hutchinson, M., Moukabary, T., Lancaster, J., Goldman, S., & Juneman, E. (2019). Monophasic action potential amplitude for substrate mapping. American Journal of Physiology-Heart and Circulatory Physiology, 317(4), H667-H673.en_US
dc.identifier.issn0363-6135
dc.identifier.pmid31347917
dc.identifier.doi10.1152/ajpheart.00225.2019
dc.identifier.urihttp://hdl.handle.net/10150/634805
dc.description.abstractAlthough radiofrequency ablation has revolutionized the management of tachyarrhythmias, the rate of arrhythmia recurrence is a large drawback. Successful substrate identification is paramount to abolishing arrhythmia, and bipolar voltage electrogram's narrow field of view can be further reduced for increased sensitivity. In this report, we perform cardiac mapping with monophasic action potential (MAP) amplitude. We hypothesize that MAP amplitude (MAPA) will provide more accurate infarct sizes than other mapping modalities via increased sensitivity to distinguish healthy myocardium from scar tissue. Using the left coronary artery ligation Sprague-Dawley rat model of ischemic heart failure, we investigate the accuracy of in vivo ventricular epicardial maps derived from MAPA, MAP duration to 90% repolarization (MAPD90), unipolar voltage amplitude (UVA), and bipolar voltage amplitude (BVA) compared with gold standard histopathological measurement of infarct size. Numerical analysis reveals discrimination of healthy myocardium versus scar tissue using MAPD90 (P = 0.0158) and UVA (P < 0.001, n = 21). MAPA and BVA decreased between healthy and border tissue (P = 0.0218 and 0.0015, respectively) and border and scar tissue (P = 0.0037 and 0.0094, respectively). Contrary to our hypothesis, BVA mapping performed most accurately regarding quantifying infarct size. MAPA mapping may have high spatial resolution for myocardial tissue characterization but was quantitatively less accurate than other mapping methods at determining infarct size. BVA mapping's superior utility has been reinforced, supporting its use in translational research and clinical electrophysiology laboratories. MAPA may hold potential value for precisely distinguishing healthy myocardium, border zone, and scar tissue in diseases of disseminated fibrosis such as atrial fibrillation. NEW & NOTEWORTHY Monophasic action potential mapping in a clinically relevant model of heart failure with potential implications for atrial fibrillation management.en_US
dc.description.sponsorshipNational Heart, Lung, and Blood InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [HL-007249-43]; WARMER Research Foundation; Martin and Carol Reid Charitable Remainder Trust; Sarver Heart Center, University of Arizonaen_US
dc.language.isoenen_US
dc.publisherAMER PHYSIOLOGICAL SOCen_US
dc.rightsCopyright © 2019 the American Physiological Societyen_US
dc.subjectaction potentialen_US
dc.subjectmappingen_US
dc.subjectraten_US
dc.subjectvoltageen_US
dc.titleMonophasic action potential amplitude for substrate mappingen_US
dc.typeArticleen_US
dc.identifier.eissn1522-1539
dc.contributor.departmentUniv Arizona, Sarver Heart Ctren_US
dc.contributor.departmentUniv Arizona, Coll Meden_US
dc.identifier.journalAMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGYen_US
dc.description.note12 month embargo; available online 19 Sep 2019en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleAmerican journal of physiology. Heart and circulatory physiology


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