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    Convection–diffusion molecular transport in a microfluidic bilayer device with a porous membrane

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    Pcdmt_manuscript_final.pdf
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    Description:
    Final Accepted Manuscript
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    Author
    Frost, Timothy S.
    Estrada, Victor
    Jiang, Linan
    Zohar, Yitshak
    Affiliation
    Univ Arizona, Dept Biomed Engn
    Univ Arizona, Dept Aerosp & Mech Engn
    Issue Date
    2019-09-21
    Keywords
    Microfluidic bilayer device
    Convection-diffusion mass transport
    Molecular concentration distribution
    
    Metadata
    Show full item record
    Publisher
    SPRINGER HEIDELBERG
    Citation
    Frost, T.S., Estrada, V., Jiang, L. et al. Microfluid Nanofluid (2019) 23: 114. https://doi.org/10.1007/s10404-019-2283-1
    Journal
    MICROFLUIDICS AND NANOFLUIDICS
    Rights
    Copyright © Springer-Verlag GmbH Germany, part of Springer Nature 2019
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The field of human cell research is rapidly changing due to the introduction of microphysiological systems, which commonly feature two stacked microchannels separated by a porous membrane for in vitro barrier modeling. An essential component to adequately representing a subset of human organ or tissue functions in these microfluidic systems is the concentration distribution of the biospecies involved. In particular, when different cell types are cultured, a delicate balance between media mixing and cellular signaling is required for long-term maintenance of the cellular co-culture. In this work, we experimentally measured the effects of various control parameters on the transient and steady average molecular concentration at the bilayer device outlet. Using these experimental results for validation, we then numerically investigated the concentration distributions due to the convection–diffusion mass transport in both microchannels. The effects of media flow rate, separation membrane porosity, molecular size, microchannel dimensions and flow direction have been systematically characterized. The transient response is found to be negligible for cell co-cultures lasting several days, while the steady-state concentration distribution is dominated by the media flow rate and separation membrane porosity. Numerically computed concentration profiles reveal self-similarity characteristics featuring a diffusive boundary layer, which can be manipulated for successful maintenance of cell co-culture with limited media mixing and enhanced cell signaling.
    Note
    12 month embargo; first online: 21 September 2019
    ISSN
    1613-4982
    DOI
    10.1007/s10404-019-2283-1
    Version
    Final accepted manuscript
    Sponsors
    Arizona Biomedical Research Commission [ABRC ADHS14-082983]; NASA Space Grant Undergraduate Internship
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10404-019-2283-1
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