Show simple item record

dc.contributor.authorAndronescu, Liana R
dc.contributor.authorBuchwald, Andrea G
dc.contributor.authorCoalson, Jenna E
dc.contributor.authorCohee, Lauren
dc.contributor.authorBauleni, Andy
dc.contributor.authorWalldorf, Jenny A
dc.contributor.authorKandangwe, Chifundo
dc.contributor.authorMzilahowa, Themba
dc.contributor.authorTaylor, Terrie E
dc.contributor.authorMathanga, Don P
dc.contributor.authorLaufer, Miriam K
dc.date.accessioned2019-10-25T21:41:16Z
dc.date.available2019-10-25T21:41:16Z
dc.date.issued2019-09-24
dc.identifier.citationAndronescu, L. R., Buchwald, A. G., Coalson, J. E., Cohee, L., Bauleni, A., Walldorf, J. A., ... & Laufer, M. K. (2019). Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi. Malaria journal, 18(1), 1-7.en_US
dc.identifier.issn1475-2875
dc.identifier.pmid31551076
dc.identifier.doi10.1186/s12936-019-2930-8
dc.identifier.urihttp://hdl.handle.net/10150/634845
dc.description.abstractBackground: Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods: From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results: There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07-2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions: Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA [U19AI089683, K24AI114996]en_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.rights© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEfficacyen_US
dc.subjectITNen_US
dc.subjectMalaria controlen_US
dc.subjectMalawien_US
dc.titleNet age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawien_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlthen_US
dc.identifier.journalMALARIA JOURNALen_US
dc.description.noteOpen access journalen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleMalaria journal
refterms.dateFOA2019-10-25T21:41:17Z


Files in this item

Thumbnail
Name:
document.pdf
Size:
833.8Kb
Format:
PDF
Description:
Final Published Version

This item appears in the following Collection(s)

Show simple item record

© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Except where otherwise noted, this item's license is described as © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.