Assessment of YAP gene polymorphisms and arsenic interaction in Mexican women with breast cancer
Lantz, R Clark
Gandolfi, A Jay
Chau, Binh T
Amistadi, Mary Kay
AffiliationUniv Arizona, Dept Cellular & Mol Med
Univ Arizona, Southwest Environm Hlth Sci Ctr
Univ Arizona, Dept Pharmacol & Toxicol
Univ Arizona, Dept Soil Water & Environm Sci
YAP rs11225161 polymorphism
YAP rs1820453 polymorphism
MetadataShow full item record
CitationMichel‐Ramirez, G, Recio‐Vega, R, Lantz, RC, et al. Assessment of YAP gene polymorphisms and arsenic interaction in Mexican women with breast cancer. J Appl Toxicol. 2019; 1– 10. https://doi.org/10.1002/jat.3907
JournalJOURNAL OF APPLIED TOXICOLOGY
Rights© 2019 John Wiley & Sons, Ltd.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractThe identification of gene-environment interactions related to breast cancer reveals the biological and molecular mechanisms underlying the disease and allows the distinction of women at high risk from women at lower risk, which could decrease the morbimortality of this neoplasm. The current study evaluated the association between polymorphisms rs1820453 and rs11225161 of the Yes-associated protein (YAP) gene in women with breast cancer exposed to arsenic (As) through drinking water. In total, 182 women were assessed for the frequency of YAP rs1820453 and rs11225161 polymorphisms and As urinary levels. The results demonstrated a positive and significant association between breast cancer and smoking, type of drinking water, and levels of AsIII , AsV and inorganic As (iAs) but not the YAP gene polymorphisms evaluated. In conclusion, our data showed that the source of drinking water and AsV and iAs urinary levels increased the risk for breast cancer, but no interactions between YAP gene polymorphisms and As urinary levels were found.
Note12 month embargo; published online: 21 October 2019
VersionFinal accepted manuscript
SponsorsUniversity of Coahuila; Superfund National Institute of Environmental Health Sciences [NIH ES-04940, NIEHS/NIH P30ES006694, P42ES004940];[CONACyT-377059]
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