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    Assessment of YAP gene polymorphisms and arsenic interaction in Mexican women with breast cancer

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    Main_Document_Breast_Cancer_YA ...
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    Author
    Michel-Ramirez, Gladis
    Recio-Vega, Rogelio
    Lantz, R Clark
    Gandolfi, A Jay
    Olivas-Calderon, Edgar
    Chau, Binh T
    Amistadi, Mary Kay
    Affiliation
    Univ Arizona, Dept Cellular & Mol Med
    Univ Arizona, Southwest Environm Hlth Sci Ctr
    Univ Arizona, Dept Pharmacol & Toxicol
    Univ Arizona, Dept Soil Water & Environm Sci
    Issue Date
    2019-10-21
    Keywords
    YAP
    YAP rs11225161 polymorphism
    YAP rs1820453 polymorphism
    Yes-associated protein
    arsenic
    breast cancer
    
    Metadata
    Show full item record
    Publisher
    WILEY
    Citation
    Michel‐Ramirez, G, Recio‐Vega, R, Lantz, RC, et al. Assessment of YAP gene polymorphisms and arsenic interaction in Mexican women with breast cancer. J Appl Toxicol. 2019; 1– 10. https://doi.org/10.1002/jat.3907
    Journal
    JOURNAL OF APPLIED TOXICOLOGY
    Rights
    © 2019 John Wiley & Sons, Ltd.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The identification of gene-environment interactions related to breast cancer reveals the biological and molecular mechanisms underlying the disease and allows the distinction of women at high risk from women at lower risk, which could decrease the morbimortality of this neoplasm. The current study evaluated the association between polymorphisms rs1820453 and rs11225161 of the Yes-associated protein (YAP) gene in women with breast cancer exposed to arsenic (As) through drinking water. In total, 182 women were assessed for the frequency of YAP rs1820453 and rs11225161 polymorphisms and As urinary levels. The results demonstrated a positive and significant association between breast cancer and smoking, type of drinking water, and levels of AsIII , AsV and inorganic As (iAs) but not the YAP gene polymorphisms evaluated. In conclusion, our data showed that the source of drinking water and AsV and iAs urinary levels increased the risk for breast cancer, but no interactions between YAP gene polymorphisms and As urinary levels were found.
    Note
    12 month embargo; published online: 21 October 2019
    ISSN
    0260-437X
    PubMed ID
    31631368
    DOI
    10.1002/jat.3907
    Version
    Final accepted manuscript
    Sponsors
    University of Coahuila; Superfund National Institute of Environmental Health Sciences [NIH ES-04940, NIEHS/NIH P30ES006694, P42ES004940];[CONACyT-377059]
    ae974a485f413a2113503eed53cd6c53
    10.1002/jat.3907
    Scopus Count
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    UA Faculty Publications

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