CC16 Levels into Adult Life Are Associated with Nitrogen Dioxide Exposure at Birth
AuthorBeamer, Paloma I
Stern, Debra A
Wright, Anne L
Martinez, Fernando D
AffiliationUniv Arizona, Inst Bio5
Univ Arizona, Asthma & Airway Dis Res Ctr
Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth
MetadataShow full item record
PublisherAMER THORACIC SOC
CitationBeamer, P. I., Furlong, M., Lothrop, N., Guerra, S., Billheimer, D., Stern, D. A., ... & Martinez, F. D. (2019). CC16 levels into adult life are associated with nitrogen dioxide exposure at birth. American journal of respiratory and critical care medicine, (ja).
RightsCopyright © 2019 by the American Thoracic Society.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractRationale: Lung function and growth are adversely associated with nitrogen dioxide (NO2) exposure. Lower levels of circulating club cell secretory protein (CC16) in childhood are also associated with subsequent decreased lung function. NO2 exposure may induce epithelial damage in lungs and alter club cell proliferation and morphology.Objectives: To determine if increased ambient NO2 levels at participants' home addresses in early life were associated with decreased levels of CC16 from age 6 to 32 years.Methods: Participants were enrolled at birth in the Tucson Children's Respiratory Study and had circulating CC16 measured at least once between age 6 and 32. Linear mixed models were used to determine the association between estimated ambient NO2 exposure at participants' home address at birth or age 6 with CC16 levels from age 6 to 32.Measurements and Main Results: NO2 exposures at birth or age 6 were available for 777 children with one or more CC16 measurement. We found a negative association between NO2 exposure and CC16 levels, with a 4.7% (95% confidence interval, -8.6 to -0.7) decrease in CC16 levels from age 6 to 32 per interquartile range increase in NO2 exposure (6.0 ppb) at the participants' birth address. We observed modification by race (p interaction = 0.04), with stronger associations among participants with at least one black parent (-29.6% [95% confidence interval, -42.9% to -13.2%] per interquartile range). NO2 at participant's age 6 address was not significantly associated with CC16 levels (-1.9%; 95% confidence interval, -6.3 to 2.6).Conclusions: Higher exposure to NO2 at birth is associated with persistently low levels of CC16 from 6 to 32 years.
Note12 month embargo; published online: 1 September 2019
VersionFinal accepted manuscript
SponsorsNIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [ES006694, AI135108, HL56177, HL103970, ES028743]; Arizona Technology and Research Initiative Fund; U.S. Environmental Protection AgencyUnited States Environmental Protection Agency [CR811806]
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